Evidence map›Paper›PMID 37961639›Full record

ArticlebioRxiv : the preprint server for biology2023

Genome Editing Outcomes Reveal Mycobacterial NucS Participates in a Short-Patch Repair of DNA Mismatches.

Tanjina Islam, Eric A Josephs

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Tanjina IslamDepartment of Nanoscience, University of North Carolina at Greensboro, Greensboro, NC, 27401, USA.
Eric A JosephsDepartment of Nanoscience, University of North Carolina at Greensboro, Greensboro, NC, 27401, USA.ORCID 0000-0002-5330-6842
University of North Carolina at Greensboro · US

Funding

Complex Mechanisms of Mutation and Mutation Avoidance in Living CellsR35GM133483 · NIGMS · UNIVERSITY OF NORTH CAROLINA GREENSBORO · PI JOSEPHS, ERIC ALAN · 2019 to 2023
$1.6M
Mechanism and Architecture of EndoMS/NucS Mutation Avoidance in MycobacteriaR21AI146876 · NIAID · UNIVERSITY OF NORTH CAROLINA GREENSBORO · PI JOSEPHS, ERIC ALAN · 2019 to 2020
$291k
NIAID NIH HHS R21 AI146876NIGMS NIH HHS R35 GM133483
6 · The paper itself

Abstract

In the canonical DNA mismatch repair (MMR) mechanism in bacteria, if during replication a nucleotide is incorrectly mis-paired with the template strand, the resulting repair of this mis-pair can result in the degradation and re-synthesis of hundreds or thousands of nucleotides on the newly-replicated strand (long-patch repair). While mycobacteria, which include important pathogens such as

Identifiers

PMID37961639
PMCPMC10634747
OpenAlexW4387895310

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.