ArticlebioRxiv : the preprint server for biology2024
Aryl hydrocarbon receptor restricts axon regeneration of DRG neurons in response to injury.
Dalia Halawani, Yiqun Wang, Molly Estill, Arthur Sefiani, Aarthi Ramakrishnan, Jiaxi Li, Haofei Ni, Daniel Halperin, Li Shen, Cédric G Geoffroy and 2 more
Open access · greenAbstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0cells of the map it votes in
0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 5 citations in OpenAlex.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
12 authors at 3 institutions in 2 countries.
Dalia HalawaniNash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, USA.ORCID 0000-0003-4738-0656 Yiqun WangNash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, USA.
Molly EstillNash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, USA.
Arthur SefianiDepartment of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A&M University, USA.
Aarthi RamakrishnanNash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, USA.ORCID 0000-0002-6329-6502 Jiaxi LiNash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, USA.
Haofei NiNash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, USA.
Daniel HalperinNash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, USA.
Li ShenNash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, USA.ORCID 0000-0002-5190-2851 Cédric G GeoffroyDepartment of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A&M University, USA.ORCID 0000-0002-7671-147X Roland H FriedelNash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, USA.ORCID 0000-0002-7513-3604 Hongyan ZouNash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, USA.ORCID 0000-0003-4216-5607 Allen Institute for Brain Science · USTexas A&M Health Science Center · USTongji University · CN
Funding
The Role of Core Circadian Regulator Bmal1 in Axonal Regeneration and Nerve RepairR01NS127442 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Hongyan Jenny Zou · 2023 to 2026
$2.2MUnderstanding the age-dependent mitochondrial function in astrocytes after spinal cord injury via bi-directional manipulation of activityR01NS128101 · NINDS · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI MICHELLE A HOOK · 2022 to 2026
$1.9MA novel adult neurons screening technology to repurpose FDA-approved drugs for spinal cord injuryR21NS131834 · NINDS · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI GEOFFROY, CEDRIC G · 2023 to 2023
$411kNINDS NIH HHS R01 NS127442NINDS NIH HHS R01 NS128101NINDS NIH HHS R21 NS131834
6 · The paper itselfAbstract
Injured neurons sense environmental cues to balance neural protection and axon regeneration, but the mechanisms are unclear. Here, we unveil aryl hydrocarbon receptor (AhR), a ligand-activated bHLH-PAS transcription factor, as a molecular sensor and key regulator of acute stress response at the expense of axon regeneration. We demonstrate responsiveness of DRG sensory neurons to AhR signaling, which functions to inhibit axon regeneration. Conditional
Indexed as
ArntAryl hydrocarbon receptor (AhR)Axon regenerationConditioning lesion of DRGDNA hydroxymethylationHypoxia-inducible factor (HIF)Integrated stress response (ISR)Spinal cord injury
Identifiers
PMID37961567
PMCPMC10635160
OpenAlexW4388373511
What OpenQuestion holds
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LicenceCC BY-NC-ND
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