Evidence map›Paper›PMID 37961546›Full record

ArticlebioRxiv : the preprint server for biology2023

Highly-parallel production of designer organoids by mosaic patterning of progenitors.

Catherine M Porter, Grace C Qian, Samuel H Grindel, Alex J Hughes

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Catherine M PorterDepartment of Bioengineering, University of Pennsylvania, Philadelphia, 19104, PA, USA.
Grace C QianDepartment of Bioengineering, University of Pennsylvania, Philadelphia, 19104, PA, USA.
Samuel H GrindelDepartment of Bioengineering, University of Pennsylvania, Philadelphia, 19104, PA, USA.
Alex J HughesDepartment of Bioengineering, University of Pennsylvania, Philadelphia, 19104, PA, USA.ORCID 0000-0001-6801-3455
California Institute for Regenerative Medicine · USUniversity of Pennsylvania · US

Funding

A developmental engineering toolbox for large-scale tissue engineeringR35GM133380 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI Alex Hughes · 2019 to 2026
$3.3M
NIGMS NIH HHS R35 GM133380
6 · The paper itself

Abstract

Human organoids are a promising approach for disease modeling and regenerative medicine. However, organoid variability and limited control over morphological outcomes remain significant challenges. Here we extend a DNA 'velcro' cell patterning approach, precisely controlling the number and ratio of human stem cell-derived progenitors contributing to nephron and mosaic nephron/ureteric bud organoids within arrays of microwells. We demonstrate long-term control over organoid size and morphology, decoupled from geometric constraints.

Identifiers

PMID37961546
PMCPMC10634829
OpenAlexW4388204178

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.