Evidence map›Paper›PMID 37961544›Full record

ArticlemedRxiv : the preprint server for health sciences2023

Altered Platelet-Megakaryocyte Endocytosis and Trafficking of Albumin and Fibrinogen in

Fabiola Del Carpio-Cano, Guangfen Mao, Lawrence E Goldfinger, Jeremy Wurtzel, Liying Guan, Afaque Mohammad Alam, Kiwon Lee, Mortimer E Poncz, A Koneti Rao

Open access · greenAbstract readPreprint
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Fabiola Del Carpio-Cano
Guangfen Mao
Lawrence E Goldfinger
Jeremy Wurtzel
Liying Guan
Afaque Mohammad Alam
Kiwon Lee
Mortimer E Poncz
Temple University · USChildren's Hospital of Philadelphia · USThomas Jefferson University · US

Funding

Human Platelet Defects in Transcription Factor RUNX1 HaplodeficiencyR01HL109568 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI RAO, ANGARA KONETI · 2013 to 2022
$3.4M
Runx1 Haplodeficiency, Endocytosis and Vesicle transportR01HL137376 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI RAO, ANGARA KONETI · 2018 to 2021
$1.8M
NHLBI NIH HHS R01 HL109568NHLBI NIH HHS R01 HL137376
6 · The paper itself

Abstract

Platelet α-granules have numerous proteins, some synthesized by megakaryocytes (MK) and others not synthesized but incorporated by endocytosis, an incompletely understood process in platelets/MK. Germline Key points: Platelet content and endocytosis of α-granule proteins, albumin, fibrinogen and IgG, are decreased in germline RUNX1 haplodeficiency. In

Identifiers

PMID37961544
PMCPMC10635164
OpenAlexW4387869400

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.