ArticlebioRxiv : the preprint server for biology2023
DrugMap: A quantitative pan-cancer analysis of cysteine ligandability.
Mariko Takahashi, Harrison B Chong, Siwen Zhang, Matthew J Lazarov, Stefan Harry, Michelle Maynard, Ryan White, Heather E Murrey, Brendan Hilbert, Jason R Neil and 59 more
Open access · greenAbstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 8 citations in OpenAlex.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
69 authors at 4 institutions in 1 country.
Mariko Takahashi
Harrison B Chong
Siwen Zhang
Matthew J Lazarov
Stefan Harry
Michelle Maynard
Ryan White
Heather E Murrey
Brendan Hilbert
Jason R Neil
Magdy Gohar
Maolin Ge
Junbing Zhang
Benedikt R Durr
Gregory Kryukov
Chih-Chiang Tsou
Natasja Brooijmans
Aliyu Sidi Omar Alghali
Karla Rubio
Antonio Vilanueva
Drew Harrison
Ann-Sophie Koglin
Samuel Ojeda
Barbara Karakyriakou
Alexander Healy
Jonathan Assaad
Farah Makram
Inbal Rachman
Neha Khandelwal
Pei-Chieh Tien
George Popoola
Nicholas Chen
Kira Vordermark
Marianne Richter
Himani Patel
Tzu-Yi Yang
Hanna Griesshaber
Tobias Hosp
Sanne van den Ouweland
Toshiro Hara
Lily Bussema
Rui Dong
Lei Shi
Martin Q Rasmussen
Ana Carolina Domingues
Aleigha Lawless
Jacy Fang
Satoshi Yoda
Linh Phuong Nguyen
Sarah Marie Reeves
Farrah Nicole Wakefield
Adam Acker
Sarah Elizabeth Clark
Taronish Dubash
Shyamala Maheswaran
Daniel A Haber
Genevieve Boland
Moshe Sade-Feldman
Russel Jenkins
Aaron Hata
Nabeel Bardeesy
Mario L Suva
Brent Martin
Brian Liau
Christopher Ott
Miguel N Rivera
Michael S Lawrence
Liron Bar-Peled
Massachusetts General Hospital · USHarvard University · USScorpion Therapeutics (United States) · USBroad Institute · US
Funding
Transcriptional mechanisms and melanomaP01CA163222 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI Kai W Wucherpfennig · 2013 to 2026
$25.3MTherapeutic strategies for treatment of giant congenital melanocytic neviR01AR072304 · NIAMS · MASSACHUSETTS GENERAL HOSPITAL · PI DAVID E FISHER · 2017 to 2026
$3.9MA druggable dependency in low-MITF/high-AXL melanoma: preclinical efficacy and mechanism of action in a key treatment-resistant subclass.R01CA222871 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI FISHER, DAVID E · 2018 to 2022
$1.8MNCI NIH HHS P01 CA163222NCI NIH HHS R01 CA222871NIAMS NIH HHS R01 AR072304
6 · The paper itselfAbstract
Cysteine-focused chemical proteomic platforms have accelerated the clinical development of covalent inhibitors of a wide-range of targets in cancer. However, how different oncogenic contexts influence cysteine targeting remains unknown. To address this question, we have developed
Identifiers
PMID37961514
PMCPMC10634688
OpenAlexW4387895448
What OpenQuestion holds
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