Evidence map›Paper›PMID 37961503›Full record

ArticlebioRxiv : the preprint server for biology2023

Pathological claustrum activity drives aberrant cognitive network processing in human chronic pain.

Brent W Stewart, Michael L Keaser, Hwiyoung Lee, Sarah M Margerison, Matthew A Cormie, Massieh Moayedi, Martin A Lindquist, Shuo Chen, Brian N Mathur, David A Seminowicz

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 3 countries.

Brent W StewartDepartment of Neural and Pain Sciences, University of Maryland School of Dentistry, Baltimore, MD, USA.ORCID 0000-0001-5737-8870
Michael L KeaserDepartment of Neural and Pain Sciences, University of Maryland School of Dentistry, Baltimore, MD, USA.
Hwiyoung LeeDepartment of Epidemiology & Public Health, Maryland Psychiatric Research Center, Catonsville, MD, USA.ORCID 0000-0002-3855-2316
Sarah M MargerisonDepartment of Neural and Pain Sciences, University of Maryland School of Dentistry, Baltimore, MD, USA.ORCID 0000-0001-6846-4328
Matthew A CormieCentre for Multimodal Sensorimotor and Pain Research, Faculty of Dentistry, University of Toronto, ON, Canada.ORCID 0009-0008-5121-9228
Massieh MoayediCentre for Multimodal Sensorimotor and Pain Research, Faculty of Dentistry, University of Toronto, ON, Canada.ORCID 0000-0002-7324-2540
Martin A LindquistDepartment of Biostatistics, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0003-2289-0828
Shuo ChenDepartment of Epidemiology & Public Health, Maryland Psychiatric Research Center, Catonsville, MD, USA.
Brian N MathurDepartment of Pharmacology, University of Maryland School of Medicine, Baltimore, MD, USA.
David A SeminowiczDepartment of Neural and Pain Sciences, University of Maryland School of Dentistry, Baltimore, MD, USA.ORCID 0000-0003-3111-3756
University of Maryland, Baltimore · USUniversity of Mary · USJohns Hopkins University · USMount Sinai Hospital · CAUniversity of Toronto · CAWestern University · CA

Funding

MRI outcomes of mindfulness meditation for migraineR01AT007176 · NCCIH · UNIVERSITY OF MARYLAND BALTIMORE · PI SEMINOWICZ, DAVID · 2013 to 2017
$3.5M
Cerebral oscillations of painR01NS112356 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI DA SILVA, JOYCE TEIXEIRA, SEMINOWICZ, DAVID · 2019 to 2022
$1.6M
NCCIH NIH HHS R01 AT007176NINDS NIH HHS R01 NS112356
6 · The paper itself

Abstract

Aberrant cognitive network activity and cognitive deficits are established features of chronic pain. However, the nature of cognitive network alterations associated with chronic pain and their underlying mechanisms require elucidation. Here, we report that the claustrum, a subcortical nucleus implicated in cognitive network modulation, is activated by acute painful stimulation and pain-predictive cues in healthy participants. Moreover, we discover pathological activity of the claustrum and a lateral aspect of the right dorsolateral prefrontal cortex (latDLPFC) in migraine patients. Dynamic causal modeling suggests a directional influence of the claustrum on activity in this latDLPFC region, and diffusion weighted imaging (DWI) verifies their structural connectivity. These findings advance understanding of claustrum function during acute pain and provide evidence of a possible circuit mechanism driving cognitive impairments in chronic pain.

Indexed as

Chronic painClaustrumCognitionCognitive controlMigraineNetworksPain

Identifiers

PMID37961503
PMCPMC10635040
OpenAlexW4388297152

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.