Evidence map›Paper›PMID 37961501›Full record

ArticleResearch square2023

Altered cord blood mitochondrial DNA content and prenatal exposure to arsenic metabolites in low-arsenic areas.

Feng Qiu, Hongling Zhang, Xin Wang, Zhenxian Jia, Yujie He, Yi Wu, Zhangpeng Li, Tongzhang Zheng, Wei Xia, Shunqing Xu and 1 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Feng QiuHuazhong University of Science and Technology Tongji Medical College.
Hongling ZhangWuchang University of Technology.
Xin WangHuazhong University of Science and Technology Tongji Medical College.
Zhenxian JiaHuazhong University of Science and Technology Tongji Medical College.
Yujie HeHuazhong University of Science and Technology Tongji Medical College.
Yi WuHuazhong University of Science and Technology Tongji Medical College.
Zhangpeng LiHuazhong University of Science and Technology Tongji Medical College.
Tongzhang ZhengBrown University.
Wei XiaHuazhong University of Science and Technology Tongji Medical College.
Shunqing XuHuazhong University of Science and Technology Tongji Medical College.
Yuanyuan LiTongji Medical College of Huazhong University of Science and Technology: Huazhong University of Science and Technology Tongji Medical College.ORCID https://orcid.org/0000-0002-2513-633X
Huazhong University of Science and Technology · CNJohn Brown University · USWuchang University of Technology · CN

Funding

A nested case-control study of exposure to toxic metals, essential metals and their interaction on the risk of type 2 diabetesR01ES029082 · NIEHS · BROWN UNIVERSITY · PI LIU, SIMIN, YANA, BAI · 2019 to 2022
$2.1M
NIEHS NIH HHS R01 ES029082
6 · The paper itself

Abstract

While mitochondria are susceptible to environmental detriments, little is known about potential associations between arsenic metabolites and mitochondria DNA copy number (mtDNAcn). We attempted to examine whether arsenic metabolism in different trimesters was related to cord blood mtDNAcn alteration. We included 819 mother-newborn pairs embedded in an in-progress birth cohort survey performed from April 2014 to October 2016 in Wuhan, China. We determined maternal urinary arsenic species concentrations in different trimesters using HPLC-ICPMS. We decided on cord blood mtDNAcn using quantitative real-time polymerase chain reaction. In covariate-adjusted models, each two-fold increment of dimethylated arsenic (DMA) and total arsenic (TAs) in the 3rd trimester were related to 8.43% (95% CI: 1.13%, 16.26%) and 12.15% (95% CI:4.35%, 20.53%) increases in mtDNAcn, respectively. The dose-response trend with statistical significance was observed across tertiles of DMA and TAs in the 3rd trimester with mtDNAcn. These findings may prove the relationships between arsenic species and mitochondrial dysfunction.

Indexed as

Arsenic Metabolismcord bloodMitochondrial DNA copy numberPrenatal exposureRepeated measurement

Identifiers

PMID37961501
PMCPMC10635372
OpenAlexW4388086762

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.