ArticlebioRxiv : the preprint server for biology2023
Cell-type-resolved somatic mosaicism reveals clonal dynamics of the human forebrain.
Changuk Chung, Xiaoxu Yang, Robert F Hevner, Katie Kennedy, Keng Ioi Vong, Yang Liu, Arzoo Patel, Rahul Nedunuri, Scott T Barton, Chelsea Barrows and 5 more
Open access · greenAbstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 4 citations in OpenAlex.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
15 authors at 3 institutions in 1 country.
Changuk ChungDepartment of Neurosciences, University of California San Diego, La Jolla, CA, 92037, USA.ORCID 0000-0003-3628-6090 Xiaoxu YangDepartment of Neurosciences, University of California San Diego, La Jolla, CA, 92037, USA.ORCID 0000-0003-0219-0023 Robert F HevnerSanford Consortium for Regenerative Medicine, La Jolla, CA, 92037, USA.
Katie KennedyBioSkryb Genomics, Inc., Durham, NC.
Keng Ioi VongDepartment of Neurosciences, University of California San Diego, La Jolla, CA, 92037, USA.ORCID 0000-0001-5377-9845 Yang LiuDepartment of Neurosciences, University of California San Diego, La Jolla, CA, 92037, USA.
Arzoo PatelDepartment of Neurosciences, University of California San Diego, La Jolla, CA, 92037, USA.
Rahul NedunuriDepartment of Neurosciences, University of California San Diego, La Jolla, CA, 92037, USA.
Scott T BartonDivision of Medical Education, School of Medicine, University of California, San Diego, La Jolla, CA, 92037, USA.ORCID 0000-0002-4996-9504 Chelsea BarrowsDepartment of Neurosciences, University of California San Diego, La Jolla, CA, 92037, USA.
Valentina StanleyDepartment of Neurosciences, University of California San Diego, La Jolla, CA, 92037, USA.
Swapnil MittalDepartment of Neurosciences, University of California San Diego, La Jolla, CA, 92037, USA.
Martin W BreussDepartment of Pediatrics, Section of Clinical Genetics and Metabolism, University of Colorado Aurora, CO, 80045, USA.ORCID 0000-0003-2200-8604 Johannes C M SchlachetzkiDepartment of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0002-7801-9743 Joseph G GleesonDepartment of Neurosciences, University of California San Diego, La Jolla, CA, 92037, USA.ORCID 0000-0002-0889-9220 Children’s Institute · USUniversity of California San Diego · USUniversity of Colorado Denver · US
Funding
Mosaicism in focal cortical dysplasias spectrum seen in neuropsychiatric diseaseU01MH108898 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLEESON, JOSEPH G · 2015 to 2019
$5.1MOrigins of Brain Somatic Mosaicism in Developmental Brain DiseaseR01MH124890 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLEESON, JOSEPH G · 2021 to 2025
$1.5MIllumina NovaSeq 6000 Sequencing SystemS10OD026929 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JEPSEN, KRISTEN LYNN · 2019 to 2019
$600kUnderstanding genomic stability between generations by assessing mutational burdens in single spermsR00HD111686 · NICHD · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Xiaoxu Yang · 2025 to 2026
$498kMechanisms controlling HIV latency and pathogenesis in microgliaR21MH134401 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SCHLACHETZKI, JOHANNES CAROLUS MAGNUS, YANG, XIAOXU · 2023 to 2023
$435kUnderstanding genomic stability betweengenerations by assessing mutational burdens in single spermsK99HD111686 · NICHD · UNIVERSITY OF UTAH · PI YANG, XIAOXU · 2023 to 2024
$232kNICHD NIH HHS K99 HD111686NICHD NIH HHS R00 HD111686NIH HHS S10 OD026929NIMH NIH HHS R01 MH124890NIMH NIH HHS R21 MH134401NIMH NIH HHS U01 MH108898
6 · The paper itselfAbstract
Debate remains around anatomic origins of specific brain cell subtypes and lineage relationships within the human forebrain. Thus, direct observation in the mature human brain is critical for a complete understanding of the structural organization and cellular origins. Here, we utilize brain mosaic variation within specific cell types as distinct indicators for clonal dynamics, denoted as cell-type-specific Mosaic Variant Barcode Analysis. From four hemispheres from two different human neurotypical donors, we identified 287 and 780 mosaic variants (MVs), respectively that were used to deconvolve clonal dynamics. Clonal spread and allelic fractions within the brain reveal that local hippocampal excitatory neurons are more lineage-restricted compared with resident neocortical excitatory neurons or resident basal ganglia GABAergic inhibitory neurons. Furthermore, simultaneous genome-transcriptome analysis at both a cell-type-specific and single-cell level suggests a dorsal neocortical origin for a subgroup of DLX1
Indexed as
brain mosaicismcell typeclonal dynamicsinhibitory neuronslineagemigrationsomaticwhole-genome sequencing
Identifiers
PMID37961480
PMCPMC10634852
OpenAlexW4387937761
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