Evidence map›Paper›PMID 37961459›Full record

ArticlebioRxiv : the preprint server for biology2023

Stability of DNA-Methylation Profiles of Biological Aging in Children and Adolescents.

Abby J deSteiguer, Laurel Raffington, Aditi Sabhlok, Peter Tanksley, Elliot M Tucker-Drob, K Paige Harden

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Abby J deSteiguerDepartment of Psychology, University of Texas at Austin, Austin, TX, USA.ORCID 0009-0005-1615-7920
Laurel RaffingtonMax Planck Research Group Biosocial - Biology, Social Disparities, and Development, Max Planck Institute for Human Development, Berlin, Germany.ORCID 0000-0002-0144-5605
Aditi SabhlokDepartment of Psychology, University of Texas at Austin, Austin, TX, USA.ORCID 0000-0001-6604-1698
Peter TanksleyPopulation Research Center, The University of Texas at Austin, Austin, TX, USA.ORCID 0000-0002-3449-2838
Elliot M Tucker-DrobDepartment of Psychology, University of Texas at Austin, Austin, TX, USA.ORCID 0000-0001-5599-6237
K Paige HardenDepartment of Psychology, University of Texas at Austin, Austin, TX, USA.ORCID 0000-0002-1557-6737
The University of Texas at Austin · USMax Planck Institute for Human Development · DE

Funding

Population Research CenterR24HD042849 · NICHD · UNIVERSITY OF TEXAS AUSTIN · PI HAYWARD, MARK D. · 2002 to 2016
$8.4M
Cortisol, Socioeconomic Status, and Genetic Influences on Cognitive DevelopmentR01HD083613 · NICHD · UNIVERSITY OF TEXAS AT AUSTIN · PI TUCKER-DROB, ELLIOT MAX · 2016 to 2020
$3.0M
Environmental, Genetic, and Epigenetic Mechanisms for Hormonal ChangeR01HD092548 · NICHD · UNIVERSITY OF TEXAS AT AUSTIN · PI HARDEN, KATHRYN PAIGE · 2019 to 2023
$3.0M
NICHD NIH HHS R01 HD083613NICHD NIH HHS R01 HD092548NICHD NIH HHS R24 HD042849
6 · The paper itself

Abstract

Background and Objectives: Methylation profile scores (MPSs) index biological aging and aging-related disease in adults and are cross-sectionally associated with social determinants of health in childhood. MPSs thus provide an opportunity to trace how aging-related biology responds to environmental changes in early life. Information regarding the stability of MPSs in early life is currently lacking. Method: We use longitudinal data from children and adolescents ages 8-18 (N = 428, M age = 12.15 years) from the Texas Twin Project. Participants contributed two waves of salivary DNA-methylation data (mean lag = 3.94 years), which were used to construct four MPSs reflecting multi-system physiological decline and mortality risk (PhenoAgeAccel and GrimAgeAccel), pace of biological aging (DunedinPACE), and cognitive function (Epigenetic- Results: All MPSs showed moderate longitudinal stability (test-retest Conclusions: Aging-related DNA-methylation patterns are less stable in childhood than has been previously observed in adulthood. Further developmental research on the methylome is necessary to understand which environmental perturbations in childhood impact trajectories of biological aging and when children are most sensitive to those impacts.

Identifiers

PMID37961459
PMCPMC10635005
OpenAlexW4388230170

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.