Evidence map›Paper›PMID 37961444›Full record

ArticlemedRxiv : the preprint server for health sciences2023

Pathways linking pulse pressure to dementia in adults with Down syndrome.

Batool Rizvi, Patrick J Lao, Mithra Sathishkumar, Lisa Taylor, Nazek Queder, Liv McMillan, Natalie Edwards, David B Keator, Eric Doran, Christy Hom and 12 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors at 4 institutions in 1 country.

Batool RizviCenter for the Neurobiology of Learning and Memory, University of California, Irvine, CA.
Patrick J LaoTaub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Mithra SathishkumarCenter for the Neurobiology of Learning and Memory, University of California, Irvine, CA.
Lisa TaylorCenter for the Neurobiology of Learning and Memory, University of California, Irvine, CA.
Nazek QuederCenter for the Neurobiology of Learning and Memory, University of California, Irvine, CA.
Liv McMillanCenter for the Neurobiology of Learning and Memory, University of California, Irvine, CA.
Natalie EdwardsTaub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
David B KeatorDepartment of Psychiatry and Human Behavior, University of California, Irvine, CA, USA.
Eric DoranDepartment of Pediatrics, University of California, Irvine, CA, USA.
Christy HomDepartment of Pediatrics, University of California, Irvine, CA, USA.
Dana NguyenDepartment of Pediatrics, University of California, Irvine, CA, USA.
H Diana RosasDepartment of Neurology, Massachusetts General Hospital, Harvard University, Boston, MA, USA.
Florence LaiDepartment of Neurology, Massachusetts General Hospital, Harvard University, Boston, MA, USA.
Nicole SchupfTaub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Jose GutierrezDepartment of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Wayne SilvermanDepartment of Pediatrics, University of California, Irvine, CA, USA.
Ira T LottDepartment of Pediatrics, University of California, Irvine, CA, USA.
Mark MapstoneDepartment of Neurology, University of California, Irvine, CA, USA.
Donna M WilcockSanders-Brown Center on Aging, College of Medicine, University of Kentucky, Lexington, KY, USA.
Elizabeth HeadDepartment of Pathology & Laboratory Medicine, University of California, Irvine, CA, USA.
Michael A YassaCenter for the Neurobiology of Learning and Memory, University of California, Irvine, CA.
Adam M BrickmanTaub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
University of California, Irvine · USColumbia University · USHarvard University · USUniversity of Kentucky · US

Funding

Project 3: Biomarkers for DS Clinical TrialsU19AG068054 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHRISTIAN, BRADLEY T, HANDEN, BENJAMIN L · 2020 to 2025
$103.7M
The Alzheimer's Disease Research Center at the University of California, IrvineP30AG066519 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Mathew Mark Blurton-Jones · 2020 to 2026
$27.9M
Biomarkers of Alzheimer's Disease in Adults with Down SyndromeU01AG051412 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LOTT, IRA T., SCHUPF, NICOLE · 2015 to 2019
$26.3M
University of Kentucky Alzheimer's Disease Research CenterP30AG072946 · NIA · UNIVERSITY OF KENTUCKY · PI LINDA J VAN ELDIK · 2021 to 2026
$23.5M
Cerebrovascular contributions to Alzheimer's disease in adults with Down SyndromeRF1AG079519 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BRICKMAN, ADAM M, HEAD, ELIZABETH · 2022 to 2022
$3.1M
Understanding the mechanisms linking small vessel cerebrovascular disease and Alzheimer's disease pathophysiology with neurodegeneration and cognition during midlifeR00AG065506 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LAO, PATRICK JORDAN · 2023 to 2025
$742k
NIA NIH HHS P30 AG066519NIA NIH HHS P30 AG072946NIA NIH HHS R00 AG065506NIA NIH HHS RF1 AG079519NIA NIH HHS U01 AG051412NIA NIH HHS U19 AG068054
6 · The paper itself

Abstract

Individuals with Down syndrome (DS) are less likely to have hypertension than neurotypical adults. However, whether blood pressure measures are associated with brain health and clinical outcomes in this population has not been studied in detail. Here, we assessed whether pulse pressure is associated with markers of cerebrovascular disease, entorhinal cortical atrophy, and diagnosis of dementia in adults with DS. Participants with DS from the Biomarkers of Alzheimer's Disease in Adults with Down Syndrome study (ADDS; n=195, age=50.6±7.2 years, 44% women, 18% diagnosed with dementia) were included. Higher pulse pressure was associated with greater global, parietal, and occipital WMH volume. Pulse pressure was not related to enlarged PVS, microbleeds, infarcts, entorhinal cortical thickness, or dementia diagnosis. However, in a serial mediation model, we found that pulse pressure was indirectly related to dementia diagnosis through parieto-occipital WMH and, subsequently through entorhinal cortical thickness. Higher pulse pressure may be a risk factor for dementia in people with DS by promoting cerebrovascular disease, which in turn affects neurodegeneration. Pulse pressure is an important determinant of brain health and clinical outcomes in individuals with Down syndrome despite the low likelihood of frank hypertension.

Indexed as

agingAlzheimer’s disease (AD)Down syndrome (DS)Pulse pressureWhite matter hyperintensities (WMH)

Identifiers

PMID37961444
PMCPMC10635215
OpenAlexW4388190313

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.