Evidence map›Paper›PMID 37961437›Full record

ArticlebioRxiv : the preprint server for biology2023

Cryo-EM structure of the Spo11 core complex bound to DNA.

You Yu, Juncheng Wang, Kaixian Liu, Zhi Zheng, Meret Arter, Corentin Claeys Bouuaert, Stephen Pu, Dinshaw J Patel, Scott Keeney

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 9 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

You YuStructural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.ORCID 0000-0002-2311-7477
Juncheng WangStructural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Kaixian LiuMolecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.ORCID 0000-0001-9711-6509
Zhi ZhengMolecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Meret ArterMolecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.ORCID 0000-0002-1734-4622
Corentin Claeys BouuaertMolecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.ORCID 0000-0001-5801-7313
Stephen PuMolecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Dinshaw J PatelStructural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.ORCID 0000-0002-9779-7778
Scott KeeneyMolecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.ORCID 0000-0002-1283-6417
Memorial Sloan Kettering Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Mechanism and regulation of meiotic recombinationR35GM118092 · NIGMS · SLOAN-KETTERING INST CAN RESEARCH · PI Scott Keeney · 2016 to 2026
$7.0M
Structural and functional principles underlying germline genome transmissionR01HD110120 · NICHD · SLOAN-KETTERING INST CAN RESEARCH · PI Scott Keeney, DINSHAW J PATEL · 2022 to 2026
$2.4M
NCI NIH HHS P30 CA008748NICHD NIH HHS R01 HD110120NIGMS NIH HHS R35 GM118092
6 · The paper itself

Abstract

The DNA double-strand breaks that initiate meiotic recombination are formed by topoisomerase relative Spo11, supported by conserved auxiliary factors. Because high-resolution structural data are lacking, many questions remain about the architecture of Spo11 and its partners and how they engage with DNA. We report cryo-EM structures at up to 3.3 Å resolution of DNA-bound core complexes of

Identifiers

PMID37961437
PMCPMC10634984
OpenAlexW4388230197

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.