Evidence map›Paper›PMID 37961425›Full record

ArticlemedRxiv : the preprint server for health sciences2023

Identification of a specific APOE transcript and functional elements associated with Alzheimer's disease.

Qiang Chen, Luis Aguirre, Huanhuan Zhao, Felix Borrego, Itziar de Rojas, Lingyan Su, Pan P Li, Bao Zhang, Erzsebet Kokovay, James D Lechleiter and 8 more

Open access · greenAbstract readPreprint
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 9 institutions in 3 countries.

Qiang Chen
Luis Aguirre
Huanhuan Zhao
Felix Borrego
Itziar de Rojas
Lingyan Su
Pan P Li
Bao Zhang
Erzsebet Kokovay
James D Lechleiter
Harald H Göring
Philip L De Jager
Joel E Kleinman
Thomas M Hyde
Agustín Ruiz
Daniel R Weinberger
Sudha Seshadri
The University of Texas Health Science Center at San Antonio · USJohns Hopkins University · USBoston University · USColumbia University · USInstituto de Salud Carlos III · ESThe University of Texas at El Paso · USThe University of Texas Rio Grande Valley · USXi'an Jiaotong University · CNYunnan Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe APOE gene is the strongest genetic risk factor for late-onset Alzheimer's Disease (LOAD). However, the gene regulatory mechanisms at this locus have not been fully characterized.

methodsTo identify novel AD-linked functional elements within the

resultsWe identified an AD-linked DISCUSSION: The novel

Identifiers

PMID37961425
PMCPMC10635228
OpenAlexW4388042388

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.