ArticlebioRxiv : the preprint server for biology2025
How a disordered linker in the Polycomb protein Polyhomeotic tunes phase separation and oligomerization.
Tim M Gemeinhardt, Roshan M Regy, Tien M Phan, Nanu Pal, Jyoti Sharma, Olga Senkovich, Andrea J Mendiola, Heather J Ledterman, Amy Henrickson, Daniel Lopes and 9 more
Open access · greenAbstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 3 citations in OpenAlex.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
19 authors at 8 institutions in 2 countries.
Roshan M RegyArtie McFerrin Department of Chemical Engineering, Texas A&M University, College Station, TX, USA.ORCID 0000-0001-7750-693X Tien M PhanArtie McFerrin Department of Chemical Engineering, Texas A&M University, College Station, TX, USA.ORCID 0000-0002-8608-7359 Nanu PalMontreal Clinical Research Institute (IRCM), Montreal, QC, Canada.
Jyoti SharmaMontreal Clinical Research Institute (IRCM), Montreal, QC, Canada.
Olga SenkovichDepartment of Biochemistry and Molecular Genetics, Midwestern University, Glendale, AZ, USA.
Andrea J MendiolaDepartment of Biochemistry and Molecular Genetics, Midwestern University, Glendale, AZ, USA.
Heather J LedtermanDepartment of Biochemistry and Molecular Genetics, Midwestern University, Glendale, AZ, USA.
Amy HenricksonDepartment of Chemistry and Biochemistry, The University of Lethbridge, Lethbridge, AB, Canada.ORCID 0000-0003-3266-5202 Daniel LopesDepartment of Chemistry and Biochemistry, City College of New York, NY, USA.
Utkarsh KapoorDepartment of Chemical and Biomedical Engineering, University of Wyoming, Laramie, WY, USA.ORCID 0000-0002-4977-3405 Djamouna SihouMontreal Clinical Research Institute (IRCM), Montreal, QC, Canada.
Young C KimCenter for Materials Physics and Technology, Naval Research Laboratory, Washington, DC, USA.
Borries DemelerDepartment of Chemistry and Biochemistry, The University of Lethbridge, Lethbridge, AB, Canada.ORCID 0000-0002-2414-9518 Chongwoo A KimDepartment of Biochemistry and Molecular Genetics, Midwestern University, Glendale, AZ, USA.
Jeetain MittalArtie McFerrin Department of Chemical Engineering, Texas A&M University, College Station, TX, USA.ORCID 0000-0002-9725-6402 Montreal Clinical Research Institute · CAMidwestern University · USTexas A&M University · USUniversity of Lethbridge · CACity College of New York · USThe Graduate Center, CUNY · USUnited States Naval Research Laboratory · USUniversity of Wyoming · US
Funding
Development of an UltraScan Meta-Scheduler for HPC Job SubmissionR01GM120600 · NIGMS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Emre H. Brookes, BORRIES DEMELER · 2016 to 2026
$3.6MLiquid-Liquid Phase Separation in Heterochromatin OrganizationR01GM136917 · NIGMS · TEXAS ENGINEERING EXPERIMENT STATION · PI MITTAL, JEETAIN · 2020 to 2023
$1.4MMultiscale Computational Models to Investigate the Role of Phase Separation in BiologyR35GM153388 · NIGMS · TEXAS ENGINEERING EXPERIMENT STATION · PI Jeetain Mittal · 2024 to 2026
$1.3MThe role of SAM polymerization in Polycomb-dependent chromatin structuresR01GM114338 · NIGMS · MIDWESTERN UNIVERSITY · PI FRANCIS, NICOLE JANE, KIM, CHONGWOO A · 2016 to 2019
$1.0MNIGMS NIH HHS R01 GM114338NIGMS NIH HHS R01 GM120600NIGMS NIH HHS R01 GM136917NIGMS NIH HHS R35 GM153388
6 · The paper itselfAbstract
Biomolecular condensates are increasingly appreciated for their function in organizing and regulating biochemical processes in cells, including chromatin function. Condensate formation and properties are encoded in protein sequence but the mechanisms linking sequence to macroscale properties are incompletely understood. Cross species comparisons can reveal mechanisms either because they identify conserved functions or because they point to important differences. Here we use
Indexed as
analytical ultracentrifugation (AUC)biochemistrybiomolecular condensatesgene regulationintrinsically disordered regions (IDRs)molecular dynamics simulationsOligomerizationphase separationPolycombSterile Alpha Motif (SAM)
Identifiers
PMID37961422
PMCPMC10634872
OpenAlexW4387970776
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
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