Evidence map›Paper›PMID 37961418›Full record

ArticlebioRxiv : the preprint server for biology2023

Differences in transcription initiation directionality underlie distinctions between plants and animals in chromatin modification patterns at genes and cis-regulatory elements.

Brianna D Silver, Courtney G Willett, Kelsey A Maher, Dongxue Wang, Roger B Deal

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Brianna D SilverDepartment of Biology, Emory University, Atlanta, GA 30322 USA.
Courtney G WillettDepartment of Biology, Emory University, Atlanta, GA 30322 USA.
Kelsey A MaherDepartment of Biology, Emory University, Atlanta, GA 30322 USA.
Dongxue WangDepartment of Biology, Emory University, Atlanta, GA 30322 USA.
Roger B DealDepartment of Biology, Emory University, Atlanta, GA 30322 USA.

Funding

PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM008490 · NIGMS · EMORY UNIVERSITY · PI BOSS, JEREMY M. · 1993 to 2022
$8.0M
Chromatin targeting and transcriptional control by the histone variant H2A.ZR01GM134245 · NIGMS · EMORY UNIVERSITY · PI DEAL, ROGER BANCROFT · 2019 to 2022
$1.2M
NIGMS NIH HHS R01 GM134245NIGMS NIH HHS T32 GM008490
6 · The paper itself

Abstract

Transcriptional initiation is among the first regulated steps controlling eukaryotic gene expression. High-throughput profiling of fungal and animal genomes has revealed that RNA Polymerase II (Pol II) often initiates transcription in both directions at the promoter transcription start site (TSS), but generally only elongates productively into the gene body. Additionally, Pol II can initiate transcription in both directions at cis-regulatory elements (CREs) such as enhancers. These bidirectional Pol II initiation events can be observed directly with methods that capture nascent transcripts, and they are also revealed indirectly by the presence of transcription-associated histone modifications on both sides of the TSS or CRE. Previous studies have shown that nascent RNAs and transcription-associated histone modifications in the model plant

Indexed as

cis-regulatory elementenhancerhistone modificationpromoterRNA polymeraseTranscription

Identifiers

PMID37961418
PMCPMC10635121

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.