Evidence map›Paper›PMID 37961411›Full record

ArticlebioRxiv : the preprint server for biology2023

Decreased fucosylation impacts epithelial integrity and increases risk for COPD.

Carter Swaby, Bonnie Yeung-Luk, Shreeti Thapa, Kristine Nishida, Arabelis Wally, Baishakhi Ghosh, Austin Niederkofler, Sean Luk, Mirit Girgis, Allison Keller and 12 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 4 institutions in 2 countries.

Carter SwabyDepartment of Chemical and Biomolecular Engineering, Johns Hopkins Whiting School of Engineering, Johns Hopkins University, Baltimore, Maryland, 21218, USA.
Bonnie Yeung-LukDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205.
Shreeti ThapaDepartment of Medicine, Johns Hopkins School of Medicine, Baltimore, 21224, Maryland, USA.
Kristine NishidaDepartment of Medicine, Johns Hopkins School of Medicine, Baltimore, 21224, Maryland, USA.
Arabelis WallyDepartment of Medicine, Johns Hopkins School of Medicine, Baltimore, 21224, Maryland, USA.
Baishakhi GhoshDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205.
Austin NiederkoflerDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205.
Sean LukDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205.
Mirit GirgisDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205.
Allison KellerDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205.
Cecilia CortezDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205.
Sahana RamaswamyDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205.
Kai WilmsenDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205.
Laura BouchéDepartment of Life Sciences, Imperial College London, London, SW7 2AZ, UK.
Anne DellDepartment of Life Sciences, Imperial College London, London, SW7 2AZ, UK.
M Bradley DrummondDivision of Pulmonary Diseases and Critical Care Medicine, University of North Carolina at Chapel Hill, Chapel Hill, 27514, USA.
Nirupama PutchaDepartment of Medicine, Johns Hopkins School of Medicine, Baltimore, 21224, Maryland, USA.
Stuart M HaslamDepartment of Life Sciences, Imperial College London, London, SW7 2AZ, UK.
Rasika MathiasDepartment of Medicine, Johns Hopkins School of Medicine, Baltimore, 21224, Maryland, USA.
Nadia N HanselDepartment of Medicine, Johns Hopkins School of Medicine, Baltimore, 21224, Maryland, USA.
Jian ShengDepartment of Engineering, Texas A&M University Corpus Christi, Corpus Christi, TX 78412, USA.
Venkataramana SidhayeDepartment of Medicine, Johns Hopkins School of Medicine, Baltimore, 21224, Maryland, USA.
Johns Hopkins University · USImperial College London · GBTexas A&M University – Corpus Christi · USUniversity of North Carolina at Chapel Hill · US

Funding

Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI Rosalie Wollett · 1985 to 2026
$208.6M
Role of E-cadherin in modulating airway epithelial function and parenchymal remodelingR01HL151107 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI SIDHAYE, VENKATARAMANA K · 2020 to 2023
$2.4M
Actin-myosin contractility promotes the development of chronic bronchitisR01HL124099 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI SIDHAYE, VENKATARAMANA K · 2017 to 2021
$2.1M
Zeiss LSM780 Confocal Microscope for a Core FacilityS10OD016374 · OD · JOHNS HOPKINS UNIVERSITY · PI KUO, SCOT CHARLES · 2013 to 2013
$584k
NCI NIH HHS P30 CA006973NHLBI NIH HHS R01 HL124099NHLBI NIH HHS R01 HL151107NIH HHS S10 OD016374
6 · The paper itself

Abstract

COPD causes significant morbidity and mortality worldwide. Epithelial damage is fundamental to disease pathogenesis, although the mechanisms driving disease remain undefined. Published evidence from a COPD cohort (SPIROMICS) and confirmed in a second cohort (COPDgene) demonstrate a polymorphism in

Identifiers

PMID37961411
PMCPMC10635007
OpenAlexW4388215448

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.