Evidence map›Paper›PMID 37961409›Full record

ArticlebioRxiv : the preprint server for biology2023

The N6-methyladenosine demethylase ALKBH5 regulates the hypoxic HBV transcriptome.

Senko Tsukuda, James M Harris, Andrea Magri, Peter Balfe, Peter Ac Wing, Aleem Siddiqui, Jane A McKeating

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Senko TsukudaNuffield Department of Medicine, University of Oxford, UK.ORCID 0000-0002-7289-3018
James M HarrisNuffield Department of Medicine, University of Oxford, UK.
Andrea MagriNuffield Department of Medicine, University of Oxford, UK.
Peter BalfeNuffield Department of Medicine, University of Oxford, UK.
Peter Ac WingChinese Academy of Medical Sciences Oxford Institute, University of Oxford, UK.
Aleem SiddiquiDivision of Infectious Diseases and Global Public Health, University of California, CA, USA.
Jane A McKeatingNuffield Department of Medicine, University of Oxford, UK.ORCID 0000-0002-7229-5886
University of Oxford · GBChinese Academy of Medical Sciences & Peking Union Medical College · CNUniversity of California System · US

Funding

Epitranscriptomic regulation of HBV gene expressionR01AI139234 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SIDDIQUI, ALEEM · 2019 to 2023
$1.8M
Epitranscriptomic regulation of HBV gene expressionR56AI139234 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SIDDIQUI, ALEEM · 2018 to 2018
$393k
NIAID NIH HHS R01 AI139234NIAID NIH HHS R56 AI139234Wellcome Trust 200838/Z/16/Z
6 · The paper itself

Abstract

Chronic hepatitis B is a global health problem and current treatments only suppress hepatitis B virus (HBV) infection, highlighting the need for new curative treatments. Oxygen levels influence HBV replication and we previously reported that hypoxia inducible factors (HIFs) activate the basal core promoter to transcribe pre-genomic RNA. Application of a probe-enriched long-read sequencing method to map the HBV transcriptome showed an increased abundance of all viral RNAs under low oxygen or hypoxic conditions. Importantly, the hypoxic-associated increase in HBV transcripts was dependent on N6-methyladenosine (m

Indexed as

ALKBH5HBVHIFhypoxiam6A

Identifiers

PMID37961409
PMCPMC10634982
OpenAlexW4388230140

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.