Evidence map›Paper›PMID 37961389›Full record

ArticlebioRxiv : the preprint server for biology2023

Excessive cortical beta oscillations are associated with slow-wave sleep dysfunction in mild parkinsonism.

Ajay K Verma, Bharadwaj Nandakumar, Kit Acedillo, Ying Yu, Ethan Marshall, David Schneck, Mark Fiecas, Jing Wang, Colum D MacKinnon, Michael J Howell and 2 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Ajay K VermaDepartment of Neurology, University of Minnesota, Minneapolis, MN, USA.
Bharadwaj NandakumarDepartment of Neurology, University of Minnesota, Minneapolis, MN, USA.
Kit AcedilloDepartment of Neurology, University of Minnesota, Minneapolis, MN, USA.
Ying YuDepartment of Neurology, University of Minnesota, Minneapolis, MN, USA.
Ethan MarshallDepartment of Neurology, University of Minnesota, Minneapolis, MN, USA.
David SchneckMasonic Institute for the Developing Brain, University of Minnesota, Minneapolis, MN, USA.
Mark FiecasDivision of Biostatistics, University of Minnesota, Minneapolis, MN, USA.
Jing WangDepartment of Neurology, University of Minnesota, Minneapolis, MN, USA.
Colum D MacKinnonDepartment of Neurology, University of Minnesota, Minneapolis, MN, USA.
Michael J HowellDepartment of Neurology, University of Minnesota, Minneapolis, MN, USA.
Jerrold L VitekDepartment of Neurology, University of Minnesota, Minneapolis, MN, USA.
Luke A JohnsonDepartment of Neurology, University of Minnesota, Minneapolis, MN, USA.
University of Minnesota · US

Funding

Understanding Circuit Dynamics in Parkinson's Disease using Real-Time Neural ControlP50NS123109 · NINDS · UNIVERSITY OF MINNESOTA · PI AMAN, JOSHUA E · 2021 to 2025
$11.3M
Neurophysiological Mechanisms Underlying Parkinsonian Motor SignsR01NS058945 · NINDS · UNIVERSITY OF MINNESOTA · PI LUKE Aaron JOHNSON, Jerrold L Vitek · 2008 to 2026
$9.6M
Pathophysiology-based approaches to deep brain stimulation for Parkinson's diseaseP50NS098573 · NINDS · UNIVERSITY OF MINNESOTA · PI JOHNSON, MATTHEW DOUGLAS · 2016 to 2020
$9.1M
The Effects of Parkinsonism and Deep Brain Stimulation on Basal Ganglia-Thalamocortical Circuitry During Sleep-Wake BehaviorR01NS110613 · NINDS · UNIVERSITY OF MINNESOTA · PI LUKE Aaron JOHNSON · 2019 to 2026
$4.7M
Neuronal Activity in MC and SMA during STN and GPi DBS in the Parkinsonian MonkeyR37NS077657 · NINDS · UNIVERSITY OF MINNESOTA · PI VITEK, JERROLD L · 2018 to 2024
$4.4M
Sleep-specific DBS therapy in Parkinson's diseaseR01NS131371 · NINDS · UNIVERSITY OF MINNESOTA · PI LUKE Aaron JOHNSON · 2023 to 2026
$2.4M
NINDS NIH HHS P50 NS098573NINDS NIH HHS P50 NS123109NINDS NIH HHS R01 NS058945NINDS NIH HHS R01 NS110613NINDS NIH HHS R01 NS131371NINDS NIH HHS R37 NS077657
6 · The paper itself

Abstract

Increasing evidence associates slow-wave sleep (SWS) dysfunction with neurodegeneration. Using a within-subject design in the nonhuman primate model of Parkinson's disease (PD), we found that reduced SWS quantity in mild parkinsonism was accompanied by elevated beta and reduced delta power during SWS in the motor cortex. Our findings support excessive beta oscillations as a mechanism for SWS dysfunction and will inform development of neuromodulation therapies for enhancing SWS in PD.

Indexed as

beta oscillationsdelta oscillationsMPTPParkinson’s diseasesleep

Identifiers

PMID37961389
PMCPMC10634920
OpenAlexW4388115656

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.