In one paragraphArticle in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 2 citations in OpenAlex.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
13 authors at 4 institutions in 1 country.
Temitayo T BamgboseDepartment of Microbiology and Immunology, Louisiana State University Health Sciences Center, Shreveport, LA, United States.ORCID 0000-0002-1628-8868 Robert M SchilkeDepartment of Microbiology and Immunology, Louisiana State University Health Sciences Center, Shreveport, LA, United States.ORCID 0000-0001-7584-8282 Oluwakemi O IgiehonDepartment of Microbiology and Immunology, Louisiana State University Health Sciences Center, Shreveport, LA, United States.ORCID 0000-0001-8497-2576 Ebubechukwu H NkadiDepartment of Microbiology and Immunology, Louisiana State University Health Sciences Center, Shreveport, LA, United States.ORCID 0000-0001-6105-2224 David CustisResearch Core Facility, Louisiana State University Health Sciences Center, Shreveport, LA, United States.
Sushma BharrhanCenter for Applied Immunology and Pathological Processes (CAIPP), Louisiana State University Health Sciences Center, Shreveport, LA, United States.ORCID 0000-0002-0526-4705 Benjamin SchwarzProteins & Chemistry Section, Research and Technologies Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Disease, Hamilton, MT.ORCID 0000-0002-5894-953X Eric BohrnsenProteins & Chemistry Section, Research and Technologies Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Disease, Hamilton, MT.ORCID 0000-0003-4327-5242 Catharine M BosioImmunity to Pulmonary Pathogens Section, Laboratory of Bacteriology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Disease, Hamilton, MT.
Rona S ScottDepartment of Microbiology and Immunology, Louisiana State University Health Sciences Center, Shreveport, LA, United States.ORCID 0000-0003-3840-9189 Arif YurdagulDepartment of Molecular and Cellular Physiology, Louisiana State University Health Shreveport, Shreveport, LA, United States.ORCID 0000-0002-7613-6313 Brian N FinckDivision of Nutritional Sciences and Obesity Medicine, Washington University School of Medicine, St. Louis, MO, United States.ORCID 0000-0001-5411-3674 Matthew D WoolardDepartment of Microbiology and Immunology, Louisiana State University Health Sciences Center, Shreveport, LA, United States.ORCID 0000-0002-8497-5838 Louisiana State University Health Sciences Center Shreveport · USNational Institute of Allergy and Infectious Diseases · USLouisiana State University · USWashington University in St. Louis · US
Funding
The Administrative CoreP01AI127335 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI Patrizia Caposio · 2017 to 2026
$24.6MProject 4-Tracking cytomegalovirus-primed long-lived NK cells in salivary glandP20GM134974 · NIGMS · LOUISIANA STATE UNIV HSC SHREVEPORT · PI ANDREW D YUROCHKO · 2021 to 2026
$15.0MDysregulations in Polyamine Metabolism During AtherosclerosisR01HL167758 · NHLBI · LOUISIANA STATE UNIV HSC SHREVEPORT · PI Arif Yurdagul · 2023 to 2026
$2.2MLipin-1 transcriptional coregulatory activity promotes macrophage pro-resolving responseR01HL163106 · NHLBI · LOUISIANA STATE UNIV HSC SHREVEPORT · PI Matthew Dale Woolard · 2023 to 2026
$2.2MLIPIN 1 AND CARDIAC METABOLISM IN THE CONTEXT OF LIPID OVERLOADR01HL119225 · NHLBI · WASHINGTON UNIVERSITY · PI FINCK, BRIAN N · 2014 to 2017
$1.5MMacrophage- associated lipin-1 lipid synthesis regulates foam cell inflammatory responsesR01HL131844 · NHLBI · LOUISIANA STATE UNIV HSC SHREVEPORT · PI WOOLARD, MATTHEW DALE · 2017 to 2020
$1.4MProcessing of Apoptotic Cell-Derived Cargo by Macrophages Continues Efferocytosis and Drives Atherosclerosis RegressionR00HL145131 · NHLBI · LOUISIANA STATE UNIV HSC SHREVEPORT · PI YURDAGUL, ARIF · 2021 to 2023
$747kNHLBI NIH HHS R00 HL145131NHLBI NIH HHS R01 HL119225NHLBI NIH HHS R01 HL131844NHLBI NIH HHS R01 HL163106NHLBI NIH HHS R01 HL167758NIAID NIH HHS P01 AI127335NIGMS NIH HHS P20 GM134974
6 · The paper itselfAbstract
Macrophages are critical to maintaining and restoring tissue homeostasis during inflammation. The lipid metabolic state of macrophages influences their function, but a deeper understanding of how lipid metabolism is regulated in pro-resolving macrophage responses is needed. Lipin-1 is a phosphatidic acid phosphatase with a transcriptional coregulatory activity (TC) that regulates lipid metabolism. We previously demonstrated that lipin-1 supports pro-resolving macrophage responses, and here, myeloid-associated lipin-1 is required for inflammation resolution, yet how lipin-1-regulated cellular mechanisms promote macrophage pro-resolution responses is unknown. We demonstrated that the loss of lipin-1 in macrophages led to increased free fatty acid, neutral lipid, and ceramide content and increased phosphorylation of acetyl-CoA carboxylase. The inhibition of the first step of lipid synthesis and transport of citrate from the mitochondria in macrophages reduced lipid content and restored efferocytosis and inflammation resolution in lipin-1
Indexed as
beta-oxidationcitratecitrate carrierefferocytosisfatty acidinflammation resolutionlipid metabolismlipid synthesisLipin-1macrophagemetabolismpro-resolving
Identifiers
PMID37961352
PMCPMC10634750
OpenAlexW4387936760
What OpenQuestion holds
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