Evidence map›Paper›PMID 37961334›Full record

ArticlebioRxiv : the preprint server for biology2023

Precision-Cut Liver Slices as an

Yongtao Wang, Ben Leaker, Guoliang Qiao, Mozhdeh Sojoodi, Ibrahim Ragab Eissa, Eliana T Epstein, Jonathan Eddy, Oizoshimoshiofu Dimowo, Georg M Lauer, Raymond T Chung and 4 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Yongtao WangDivision of Gastrointestinal and Oncologic Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.ORCID 0000-0002-5640-4720
Ben LeakerWellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
Guoliang QiaoDivision of Gastrointestinal and Oncologic Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
Mozhdeh SojoodiDivision of Gastrointestinal and Oncologic Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
Ibrahim Ragab EissaDivision of Gastrointestinal and Oncologic Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
Eliana T EpsteinLiver Center, Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
Jonathan EddyLiver Center, Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
Oizoshimoshiofu DimowoLiver Center, Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
Georg M LauerLiver Center, Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
Raymond T ChungLiver Center, Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
Motaz QadanDivision of Gastrointestinal and Oncologic Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
Michael LanutiDivision of Thoracic Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
Bryan C FuchsDivision of Gastrointestinal and Oncologic Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
Kenneth K TanabeDivision of Gastrointestinal and Oncologic Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
Harvard University · US

Funding

Molecular Imaging of Liver FibrosisR01DK104956 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI TANABE, KENNETH K · 2015 to 2019
$2.7M
NIDDK NIH HHS R01 DK104956
6 · The paper itself

Abstract

Background: Precision-Cut Liver Slices (PCLS) are an Methods: PCLS of 250 μm thickness were prepared from four different murine fibrotic liver models: choline-deficient, L-amino acid-defined, high-fat diet (CDAHFD), thioacetamide (TAA), diethylnitrosamine (DEN), and carbon tetrachloride (CCl Results: PCLS viability in culture was stable for 72 hours. Treatment of erlotinib, an EGFR inhibitor significantly inhibited the expression of profibrogenic genes Conclusion: The responses to antifibrotic interventions can be detected and quantified with PCLS at the gene expression level. The antifibrotic effects of erlotinib are consistent between PCLS models of murine cirrhosis and those observed

Identifiers

PMID37961334
PMCPMC10635008
OpenAlexW4388228974

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.