Evidence map›Paper›PMID 37961329›Full record

ArticlemedRxiv : the preprint server for health sciences2023

White matter hyperintensities modify relationships between corticospinal tract damage and motor outcomes after stroke.

Jennifer K Ferris, Bethany P Lo, Giuseppe Barisano, Amy Brodtmann, Cathrin M Buetefisch, Adriana B Conforto, Miranda H Donnelly, Natalia Egorova-Brumley, Kathryn S Hayward, Mohamed Salah Khlif and 4 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 9 institutions in 4 countries.

Jennifer K FerrisGerontology Research Centre, Simon Fraser University, Vancouver, British Columbia, Canada.ORCID 0000-0003-3624-6996
Bethany P LoChan Division of Occupational Science and Occupational Therapy, University of Southern California, Los Angeles, California, USA.ORCID 0000-0001-7626-9020
Giuseppe BarisanoDepartment of Neurosurgery, Stanford School of Medicine, Stanford University, California, USA.ORCID 0000-0001-5598-1369
Amy BrodtmannCentral Clinical School, Monash University, Melbourne, Victoria, Australia.ORCID 0000-0001-9466-2862
Cathrin M BuetefischDepartment of Neurology, Emory University, Atlanta, Georgia, USA.ORCID 0000-0001-6473-7800
Adriana B ConfortoHospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.ORCID 0000-0001-7869-3490
Miranda H DonnellyChan Division of Occupational Science and Occupational Therapy, University of Southern California, Los Angeles, California, USA.ORCID 0000-0002-1983-3008
Natalia Egorova-BrumleyMelbourne School of Psychological Sciences, University of Melbourne, Melbourne, Victoria, Australia.ORCID 0000-0002-9244-2900
Kathryn S HaywardDepartments of Physiotherapy, Medicine (RMH) & The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria, Australia.ORCID 0000-0001-5240-3264
Mohamed Salah KhlifCentral Clinical School, Monash University, Melbourne, Victoria, Australia.ORCID 0000-0002-0096-434X
Kate P RevillFacility for Education and Research in Neuroscience, Emory University, Atlanta, Georgia, USA.ORCID 0000-0001-9497-7987
Artemis Zavaliangos-PetropuluBrain Mapping Center, Department of Neurology, Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.ORCID 0000-0003-1953-8663
Lara A BoydDepartment of Physical Therapy and Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia, Canada.ORCID 0000-0002-2828-4549
Sook-Lei LiewChan Division of Occupational Science and Occupational Therapy, University of Southern California, Los Angeles, California, USA.ORCID 0000-0001-5935-4215
University of Southern California · USEmory University · USThe University of Melbourne · AUUniversity of British Columbia · CAHospital Israelita Albert Einstein · BRMonash University · AUStanford University · USThe Royal Melbourne Hospital · AUUniversity of California, Los Angeles · US

Funding

Supplement to Effects of global brain health on sensorimotor recovery after strokeR01NS115845 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI LIEW, SOOK-LEI · 2020 to 2024
$3.2M
Customized cortical stimulation therapy in the rehabilitation of stroke patientsR01NS090677 · NINDS · EMORY UNIVERSITY · PI BUETEFISCH, CATHRIN M · 2015 to 2018
$3.0M
Reorganizing motor cortex in stroke patient through Hebbian-type stimulationR21HD067906 · NICHD · EMORY UNIVERSITY · PI BUETEFISCH, CATHRIN M · 2011 to 2012
$464k
Combined brain and peripheral nerve stimulation to enhance beneficial effects ofR01NS076348 · NINDS · FUNDACAO FACULDADE DE MEDICINA · PI CONFORTO, ADRIANA B · 2012 to 2015
$441k
NICHD NIH HHS R21 HD067906NINDS NIH HHS R01 NS076348NINDS NIH HHS R01 NS090677NINDS NIH HHS R01 NS115845
6 · The paper itself

Abstract

Motor outcomes after stroke relate to corticospinal tract (CST) damage. Concurrent damage from white matter hyperintensities (WMHs) might impact neurological capacity for recovery after CST injury. Here, we evaluated if WMHs modulate the relationship between CST damage and post-stroke motor impairment outcome. We included 223 individuals from the ENIGMA Stroke Recovery Working Group. CST damage was indexed with weighted CST lesion load (CST-LL). Mixed effects beta-regression models were fit to test the impact of CST-LL, WMH volume, and their interaction on motor impairment. WMH volume related to motor impairment above and beyond CST-LL (β = 0.178, p = 0.022). We tested if relationships varied by WMH severity (mild vs. moderate-severe). In individuals with mild WMHs, motor impairment related to CST-LL (β = 0.888, p < 0.001) with a CST-LL x WMH interaction (β = -0.211, 0.026). In individuals with moderate-severe WMHs, motor impairment related to WMH volume (β = 0.299, p = 0.044), but did not significantly relate to CST-LL or a CST-LL x WMH interaction. WMH-related damage may be under-recognised in stroke research as a factor contributing to variability in motor outcomes. Our findings emphasize the importance of brain structural reserve in motor outcomes after brain injury.

Identifiers

PMID37961329
PMCPMC10635227
OpenAlexW4388106547

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.