Evidence map›Paper›PMID 37961322›Full record

ArticlemedRxiv : the preprint server for health sciences2023

DNA methylation effects on Van der Woude Syndrome phenotypic variability.

Amanda Seaberg, Waheed Awotoye, Fang Qian, Lindsey Dunlay, Azeez Butali, Jeff Murray, Lina Moreno-Uribe, Aline Petrin

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Amanda Seaberg
Waheed AwotoyeORCID 0000-0002-5223-6846
Fang Qian
Lindsey Dunlay
Azeez ButaliORCID 0000-0002-1229-5964
Jeff Murray
Lina Moreno-Uribe
Aline PetrinORCID 0000-0003-2239-8120
University of Iowa · USIowa State University · US

Funding

Molecular Genetic Epidemiology of Cleft Lip and PalateR37DE008559 · NIDCR · UNIVERSITY OF IOWA · PI MURRAY, JEFFREY C · 2004 to 2013
$6.8M
A Twin Approach for Genome-Wide Differential DNA Methylation in Orofacial CleftingK01DE027995 · NIDCR · UNIVERSITY OF IOWA · PI PETRIN, ALINE L · 2019 to 2023
$696k
NIDCR NIH HHS K01 DE027995NIDCR NIH HHS R37 DE008559
6 · The paper itself

Abstract

objectiveVan der Woude Syndrome (VWS) classically presents with combinations of lip pits (LP) and orofacial clefts, with marked phenotypic discordance even amongst individuals carrying the same mutation. Such discordance suggests a possible role for epigenetic factors as phenotypic modifiers. Both

methodsWe measured DNAm levels of CpG sites located in the promoter regions of

resultsCpG sites in the

conclusionResults indicated that hypermethylation of the

Identifiers

PMID37961322
PMCPMC10635279
OpenAlexW4388377060

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.