Evidence map›Paper›PMID 37961308›Full record

ArticlemedRxiv : the preprint server for health sciences2023

Autophagy gene expression in skeletal muscle of older individuals is associated with physical performance, muscle volume and mitochondrial function in the Study of Muscle, Mobility and Aging (SOMMA).

Paul M Coen, Zhiguang Huo, Gregory J Tranah, Haley N Barnes, Peggy M Cawthon, Russell T Hepple, Frederico G S Toledo, Daniel S Evans, Olaya Santiago Fernández, Ana Maria Cuervo and 4 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 1 country.

Paul M CoenTranslational Research Institute, Advent Health, Orlando, Florida, USA.ORCID 0000-0002-2805-2115
Zhiguang HuoDepartment of Biostatistics, College of Public Health & Health Professions, College of Medicine University of Florida, Gainesville, Florida, USA.
Gregory J TranahCalifornia Pacific Medical Center Research Institute, San Francisco, California, USA.
Haley N BarnesCalifornia Pacific Medical Center Research Institute, San Francisco, California, USA.
Peggy M CawthonCalifornia Pacific Medical Center Research Institute, San Francisco, California, USA.
Russell T HeppleDepartment of Physical Therapy, University of Florida, Gainesville, Florida, USA.
Frederico G S ToledoDepartment of Medicine, Division of Endocrinology and Metabolism, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Daniel S EvansCalifornia Pacific Medical Center Research Institute, San Francisco, California, USA.
Olaya Santiago FernándezDepartment of Developmental & Molecular Biology, Albert Einstein College of Medicine, New York, New York, USA.
Ana Maria CuervoDepartment of Developmental & Molecular Biology, Albert Einstein College of Medicine, New York, New York, USA.
Steven B KritchevskyDepartment of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Anne B NewmanDepartment of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
Steven R CummingsCalifornia Pacific Medical Center Research Institute, San Francisco, California, USA.
Karyn A EsserDepartment of Physiology and Ageing, College of Medicine, University of Florida, Gainesville, FL, USA.
University of California, San Francisco · USUniversity of Florida · USAlbert Einstein College of Medicine · USCalifornia Pacific Medical Center · USUniversity of Pittsburgh · USAdventHealth Orlando · USWake Forest University · US

Funding

Study of Muscle, Mobility and Aging: SOMMA2R01AG059416 · NIA · CALIFORNIA PACIFIC MED CTR RES INSTITUTE · PI STEVEN RON CUMMINGS, Peggy Mannen Cawthon · 2018 to 2026
$70.3M
Wake Forest Claude D. Pepper OAIC - RenewalP30AG021332 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Jamie Nicole Justice · 2002 to 2026
$36.4M
Role of Autophagy in T Cell Function and Immunosenescence (Project 3)P01AG031782 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI MACIAN, FERNANDO · 2009 to 2024
$36.2M
Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
VARIABILITY, STABILITY & SMOOTHNESS OF WALKINGP30AG024827 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JENNIFER S BRACH · 2004 to 2026
$28.6M
Einstein's Nathan Shock Center of Excellence in Basic Biology of AgingP30AG038072 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI VIJG, JAN · 2010 to 2024
$10.8M
NCATS NIH HHS UL1 TR001420NIA NIH HHS P01 AG031782NIA NIH HHS P30 AG021332NIA NIH HHS P30 AG024827NIA NIH HHS P30 AG038072NIA NIH HHS R01 AG059416
6 · The paper itself

Abstract

Autophagy is an essential component of proteostasis and a key pathway in aging. Identifying associations between autophagy gene expression patterns in skeletal muscle and physical performance outcomes would further our knowledge of mechanisms related with proteostasis and healthy aging. Muscle biopsies were obtained from participants in the Study of Muscle, Mobility and Aging (SOMMA). For 575 participants, RNA was sequenced and expression of 281 genes related to autophagy regulation, mitophagy and mTOR/upstream pathways were determined. Associations between gene expression and outcomes including mitochondrial respiration in muscle fiber bundles (MAX OXPHOS), physical performance (VO

Indexed as

agingAutophagygene expressionmitochondriamobilitymToroxidative metabolism

Identifiers

PMID37961308
PMCPMC10635272
OpenAlexW4388376838

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.