Evidence map›Paper›PMID 37961274›Full record

ArticlebioRxiv : the preprint server for biology2024

High temporal frequency light response in mouse retina requires FAT3 signaling in bipolar cells.

Evelyn C Avilés, Sean K Wang, Sarina Patel, Shuxiang Shi, Lucas Lin, Vladimir J Kefalov, Lisa V Goodrich, Constance L Cepko, Yunlu Xue

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 4 countries.

Evelyn C AvilésDepartment of Neurobiology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115.
Sean K WangDepartments of Genetics and Ophthalmology, Harvard Medical School, Boston, MA 02115.ORCID 0000-0003-1557-8510
Sarina PatelDepartment of Neurobiology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115.
Shuxiang ShiLingang Laboratory, Shanghai, China, 200031.
Lucas LinDepartments of Genetics and Ophthalmology, Harvard Medical School, Boston, MA 02115.
Vladimir J KefalovGavin Herbert Eye Institute & Center for Translational Vision Research, University of California, Irvine, CA 92697.
Lisa V GoodrichDepartment of Neurobiology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115.
Constance L CepkoDepartments of Genetics and Ophthalmology, Harvard Medical School, Boston, MA 02115.
Yunlu XueDepartments of Genetics and Ophthalmology, Harvard Medical School, Boston, MA 02115.ORCID 0000-0002-2088-9826
Harvard University · USHoward Hughes Medical Institute · USShanghaiTech University · CNVision Eye Institute · AU

Funding

Genetic Analysis and Manipulation Core (GAEC)P50HD105351 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI Hisashi Umemori · 2021 to 2026
$9.4M
Opsin signaling in mammalian rod photoreceptorsR01EY030912 · NEI · WASHINGTON UNIVERSITY · PI KEFALOV, VLADIMIR JIVKOV, PALCZEWSKI, KRZYSZTOF · 2020 to 2023
$1.6M
Investigation of the Mechanisms of Cone Degeneration in Retinitis PigmentosaK99EY030951 · NEI · HARVARD MEDICAL SCHOOL · PI XUE, YUNLU · 2020 to 2022
$242k
NEI NIH HHS K99 EY030951NEI NIH HHS R01 EY030912NICHD NIH HHS P50 HD105351
6 · The paper itself

Abstract

Vision is initiated by the reception of light by photoreceptors and subsequent processing via downstream retinal neurons. Proper cellular organization depends on the multi-functional tissue polarity protein FAT3, which is required for amacrine cell connectivity and retinal lamination. Here we investigated the retinal function of

Indexed as

bipolar cellsFAT cadherinsGRIK1high frequency visionretinal physiology

Identifiers

PMID37961274
PMCPMC10635074
OpenAlexW4388384213

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.