Evidence map›Paper›PMID 37961244›Full record

ArticleResearch square2023

Ca2+ fortified oral rehydration solution is effective in reducing diarrhea morbidity in cholera toxin-pretreated mice.

Lieqi Tang, Shi Jin, Steven Winesett, Jane Harrell, Johnathan Fraebel, Sam X Cheng

Open access · greenAbstract readPreprint
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Lieqi TangUniversity of Florida.
Shi JinUniversity of Florida.
Steven WinesettMalcom Randall VA Medical Center.
Jane HarrellUniversity of Florida School of Medicine.
Johnathan FraebelUniversity of Florida School of Medicine.
Sam X ChengUniversity of Florida.
University of Florida · USMalcom Randall VA Medical Center · US

Funding

Calcium Receptor Action in Childhood DiarrheaK08HD079674 · NICHD · UNIVERSITY OF FLORIDA · PI CHENG, SAM X · 2014 to 2018
$671k
Next generation ORS: Randomized controlled trial comparing ORS with calcium vs standard ORS in reducing severity of adults with acute watery diarrheaR21AI169282 · NIAID · UNIVERSITY OF FLORIDA · PI CHENG, SAM X · 2023 to 2024
$390k
Development of CaSR nutrient therapy for childhood diarrheaR41HD092133 · NICHD · MEDOSOME BIOTEC, LLC · PI CHENG, SAM X · 2017 to 2017
$224k
NIAID NIH HHS R21 AI169282NICHD NIH HHS K08 HD079674NICHD NIH HHS R41 HD092133
6 · The paper itself

Abstract

Diarrhea like cholera remains a leading cause of mortality and morbidity globally. Oral rehydration solution (ORS) that developed in 1970s significantly decreases diarrhea mortality; yet, it does not reduce diarrhea morbidity and its usage has reduced persistently. Patients with diarrhea lose not only monovalent ions Na

Identifiers

PMID37961244
PMCPMC10635371
OpenAlexW4387997001

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.