Evidence map›Paper›PMID 37961230›Full record

ArticlebioRxiv : the preprint server for biology2024

Glucose Challenge Uncovers Temporal Fungibility of Metabolic Homeostasis over a day:night cycle.

Dania M Malik, Seth D Rhoades, Shirley L Zhang, Arjun Sengupta, Annika Barber, Paula Haynes, Erna Sif Arnadottir, Allan Pack, Richard G Kibbey, Pinky Kain and 2 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Dania M MalikPharmacology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Seth D RhoadesPharmacology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Shirley L ZhangChronobiology and Sleep Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Arjun SenguptaDepartment of Systems Pharmacology and Translational Therapeutics.
Annika BarberChronobiology and Sleep Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Paula HaynesChronobiology and Sleep Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Erna Sif ArnadottirDivision of Sleep Medicine, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Allan PackDivision of Sleep Medicine, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Richard G KibbeyDepartment of Internal Medicine, Department of Cellular & Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA.
Pinky KainDepartment of Systems Pharmacology and Translational Therapeutics.
Amita SehgalChronobiology and Sleep Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Aalim M WeljieDepartment of Systems Pharmacology and Translational Therapeutics.
Translational Therapeutics (United States) · USHoward Hughes Medical Institute · USSleepMed · USRutgers, The State University of New Jersey · USSleep Management Institute · USYale University · US

Funding

PREDOCTORAL TRAINING PROGRAM IN PHARMACOLOGYT32GM008076 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI BLENDY, JULIE A · 1985 to 2023
$10.8M
Mitochondrial ADP privation: A unifying model for glucose-induced insulin secretion.R01DK127637 · NIDDK · YALE UNIVERSITY · PI KIBBEY, RICHARD G, MERRINS, MATTHEW J. · 2021 to 2025
$3.4M
Balance of sleep and circadian metabolic switches in DrosophilaR01DK120757 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI SEHGAL, AMITA, WELJIE, AALIM M · 2019 to 2022
$2.1M
NIDDK NIH HHS R01 DK120757NIDDK NIH HHS R01 DK127637NIGMS NIH HHS T32 GM008076
6 · The paper itself

Abstract

Rhythmicity is a cornerstone of behavioral and biological processes, especially metabolism, yet the mechanisms behind metabolite cycling remain elusive. This study uncovers a robust oscillation in key metabolite pathways downstream of glucose in humans. A purpose-built

Indexed as

ChronobiologyCircadian ClockDiabetesDiurnal RhythmicityFeeding RhythmsGlucose MetabolismLC-MSMetabolic TracingObesityUltradian Rhythmicity

Identifiers

PMID37961230
PMCPMC10634956
OpenAlexW4388213677

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.