Evidence map›Paper›PMID 37961223›Full record

ArticlebioRxiv : the preprint server for biology2023

Breast Cancer Macrophage Heterogeneity and Self-renewal are Determined by Spatial Localization.

Nir Ben-Chetrit, Xiang Niu, Jesus Sotelo, Ariel D Swett, Vinagolu K Rajasekhar, Maria S Jiao, Caitlin M Stewart, Priya Bhardwaj, Sanjay Kottapalli, Saravanan Ganesan and 12 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 10 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 4 institutions in 3 countries.

Nir Ben-ChetritSandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0003-1112-0537
Xiang NiuSandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Jesus SoteloSandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Ariel D SwettSandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Vinagolu K RajasekharOrthopedic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Maria S JiaoCenter of Comparative Medicine and Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Caitlin M StewartSandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Priya BhardwajDepartment of Medicine, Weill Cornell Medical College, New York, NY, USA.
Sanjay KottapalliSandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Saravanan GanesanSandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Pierre-Louis LoyherImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Catherine PotenskiSandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Assaf HannunaDepartment of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel.
Kristy A BrownDepartment of Medicine, Weill Cornell Medical College, New York, NY, USA.
Neil M IyengarDepartment of Medicine, Weill Cornell Medical College, New York, NY, USA.
Dilip D GiriDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Scott W LoweCancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
John H HealeyCenter of Comparative Medicine and Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Frederic GeissmannImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Irit SagiDepartment of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel.
Johanna A JoyceDepartment of Oncology and Ludwig Institute for Cancer Research, University of Lausanne, Switzerland.
Dan A LandauSandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Cornell University · USMemorial Sloan Kettering Cancer Center · USWeizmann Institute of Science · ILLudwig Cancer Research · CH

Funding

Shapeshifters in Cancer: Defining the Fundamental Forces of Leukemia EvolutionDP2CA239065 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI LANDAU, DAN · 2018 to 2018
$2.5M
NCI NIH HHS DP2 CA239065
6 · The paper itself

Abstract

Tumor-infiltrating macrophages support critical steps in tumor progression, and their accumulation in the tumor microenvironment (TME) is associated with adverse outcomes and therapeutic resistance across human cancers. In the TME, macrophages adopt diverse phenotypic alterations, giving rise to heterogeneous immune activation states and induction of cell cycle. While the transcriptional profiles of these activation states are well-annotated across human cancers, the underlying signals that regulate macrophage heterogeneity and accumulation remain incompletely understood. Here, we leveraged a novel

Indexed as

breast cancermacrophage self-renewalspatial transcriptomicstumor-associated macrophagestumor microenvironment

Identifiers

PMID37961223
PMCPMC10634790
OpenAlexW4387976814

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.