Evidence map›Paper›PMID 37961213›Full record

ArticlebioRxiv : the preprint server for biology2023

Human iPSC-derived microglia sense and dampen hyperexcitability of cortical neurons carrying the epilepsy-associated SCN2A-L1342P mutation.

Zhefu Que, Maria I Olivero-Acosta, Ian Chen, Jingliang Zhang, Kyle Wettschurack, Jiaxiang Wu, Tiange Xiao, C Max Otterbacher, Muhan Wang, Hope Harlow and 12 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors at 4 institutions in 1 country.

Zhefu QueBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907.
Maria I Olivero-AcostaBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907.
Ian ChenBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907.
Jingliang ZhangBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907.
Kyle WettschurackBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907.
Jiaxiang WuBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907.
Tiange XiaoBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907.
C Max OtterbacherBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907.
Muhan WangBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907.
Hope HarlowBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907.
Ningren CuiBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907.
Xiaoling ChenBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907.
Brody DemingBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907.
Manasi HalurkarBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907.
Yuanrui ZhaoBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907.
Jean-Christophe RochetBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907.
Ranjie XuPurdue University College of Veterinary Medicine, West Lafayette, IN 47907.
Amy L BrewsterDepartment of Biological Sciences, Southern Methodist University, Dallas TX 75205.
Long-Jun WuDepartment of Neurology at Mayo Clinic, Rochester MN 55905.
Chongli YuanDepartment of Chemical Engineering, Purdue University, West Lafayette, IN 47907.
William C SkarnesThe Jackson Laboratory for Genomic Medicine, Farmington, CT 06032.
Yang YangBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907.ORCID 0000-0001-6417-3654
Purdue University West Lafayette · USJackson Laboratory · USMayo Clinic · USSouthern Methodist University · US

Funding

Quality Assurance and Quality Control Project Management: Improving Submissions and Study Conduct in the Human Subjects Research Prior Approval ProcessUL1TR002529 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI MOE, SHARON M, WIEHE, SARAH ELIZABETH · 2018 to 2022
$27.2M
Neuronal and Behavioral Deficits Associated with Scn2a Deficiency in Autism Spectrum DisorderR01NS117585 · NINDS · PURDUE UNIVERSITY · PI YANG, YANG · 2021 to 2025
$2.0M
Neuronal hyperexcitability and seizures in a Scn2a deficient mouse modelR01NS123154 · NINDS · PURDUE UNIVERSITY · PI YANG, YANG · 2021 to 2025
$1.9M
NCATS NIH HHS UL1 TR002529NINDS NIH HHS R01 NS117585NINDS NIH HHS R01 NS123154
6 · The paper itself

Abstract

Neuronal hyperexcitability is a hallmark of seizures. It has been recently shown in rodent models of seizures that microglia, the brain's resident immune cells, can respond to and modulate neuronal excitability. However, how human microglia interacts with human neurons to regulate hyperexcitability mediated by epilepsy-causing genetic mutation found in human patients remains unknown. The

Indexed as

channelopathyelectrophysiologyhuman induced pluripotent stem cells (hiPSCs)hyperexcitabilitymonogenic diseasesseizuresvoltage-gated sodium channel Nav1.2

Identifiers

PMID37961213
PMCPMC10634902
OpenAlexW4388090969

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.