Evidence map›Paper›PMID 37961192›Full record

ArticlebioRxiv : the preprint server for biology2023

Medial temporal lobe functional network architecture supports sleep-related emotional memory processing in older adults.

Miranda G Chappel-Farley, Jenna N Adams, Richard F Betzel, John C Janecek, Negin S Sattari, Destiny E Berisha, Novelle J Meza, Hamid Niknazar, Soyun Kim, Abhishek Dave and 6 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 1 country.

Miranda G Chappel-FarleyDepartment of Neurobiology and Behavior, University of California Irvine, Irvine CA, 92697, USA.ORCID 0000-0003-1349-0507
Jenna N AdamsDepartment of Neurobiology and Behavior, University of California Irvine, Irvine CA, 92697, USA.
Richard F BetzelDepartment of Psychological and Brain Sciences, University of Indiana Bloomington, Bloomington IN, 47405.
John C JanecekDepartment of Neurobiology and Behavior, University of California Irvine, Irvine CA, 92697, USA.
Negin S SattariDepartment of Psychiatry and Human Behavior, University of California Irvine, Irvine CA, 92697, USA.
Destiny E BerishaDepartment of Neurobiology and Behavior, University of California Irvine, Irvine CA, 92697, USA.
Novelle J MezaDepartment of Neurobiology and Behavior, University of California Irvine, Irvine CA, 92697, USA.
Hamid NiknazarDepartment of Cognitive Sciences, University of California Irvine, Irvine CA, 92697, USA.
Soyun KimDepartment of Neurobiology and Behavior, University of California Irvine, Irvine CA, 92697, USA.
Abhishek DaveDepartment of Cognitive Sciences, University of California Irvine, Irvine CA, 92697, USA.
Ivy Y ChenDepartment of Psychiatry and Human Behavior, University of California Irvine, Irvine CA, 92697, USA.
Kitty K LuiSan Diego State University/University of California San Diego, Joint Doctoral Program in Clinical Psychology, San Diego, CA, 92093, USA.
Ariel B NeikrugDepartment of Psychiatry and Human Behavior, University of California Irvine, Irvine CA, 92697, USA.
Ruth M BencaDepartment of Neurobiology and Behavior, University of California Irvine, Irvine CA, 92697, USA.
Michael A YassaDepartment of Neurobiology and Behavior, University of California Irvine, Irvine CA, 92697, USA.
Bryce A ManderCenter for the Neurobiology of Learning and Memory, University of California Irvine, Irvine CA, 92697, USA.
University of California, Irvine · USIndiana University Bloomington · USSan Diego State University · USUniversity of Wisconsin–Madison · US

Funding

Neuroimaging biomarkers for cognitive decline in elderly with amyloid pathologyR01AG053555 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Michael A Yassa · 2017 to 2026
$17.0M
Effect of hippocampal tau pathology on CA1 function and memory processing in agingF32AG074621 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI ADAMS, JENNA NICOLE · 2021 to 2023
$202k
Neurobiological mechanisms of sleep and exercise effects on memory in older adults at risk for Alzheimer's diseaseF31AG074703 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI CHAPPEL-FARLEY, MIRANDA · 2021 to 2023
$111k
NIA NIH HHS F31 AG074703NIA NIH HHS F32 AG074621NIA NIH HHS R01 AG053555
6 · The paper itself

Abstract

Memory consolidation occurs via reactivation of a hippocampal index during non-rapid eye movement slow-wave sleep (NREM SWS) which binds attributes of an experience existing within cortical modules. For memories containing emotional content, hippocampal-amygdala dynamics facilitate consolidation over a sleep bout. This study tested if modularity and centrality-graph theoretical measures that index the level of segregation/integration in a system and the relative import of its nodes-map onto central tenets of memory consolidation theory and sleep-related processing. Findings indicate that greater network integration is tied to overnight emotional memory retention via NREM SWS expression. Greater hippocampal and amygdala influence over network organization supports emotional memory retention, and hippocampal or amygdala control over information flow are differentially associated with distinct stages of memory processing. These centrality measures are also tied to the local expression and coupling of key sleep oscillations tied to sleep-dependent memory consolidation. These findings suggest that measures of intrinsic network connectivity may predict the capacity of brain functional networks to acquire, consolidate, and retrieve emotional memories.

Indexed as

consolidationgraph theorymemorynetworksresting-statesleep

Identifiers

PMID37961192
PMCPMC10634911
OpenAlexW4388160847

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.