Evidence map›Paper›PMID 37960892›Full record

SynthesisClinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis

Shell Versus Core Architecture and Biology of Thrombi in Acute Ischemic Stroke: A Systematic Review.

Oana Madalina Mereuta, Tamanna Agarwal, Sherief Ghozy, Daying Dai, Santhosh Arul, Waleed Brinjikji, David F Kallmes, Ram Kadirvel

Open access · goldAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Oana Madalina MereutaDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0003-3741-3784
Tamanna AgarwalFaculty of Medicine in Hradec Kralove, Charles University, Prague, Czech Republic.ORCID 0000-0002-4508-4776
Sherief GhozyDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.
Daying DaiDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.
Santhosh ArulDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.
Waleed BrinjikjiDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.
David F KallmesDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.
Ram KadirvelDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.
Mayo Clinic in Arizona · USCharles University · CZ

Funding

Impact of Clot Histological and Physical Properties on Revascularization Strategies in Acute Ischaemic Stroke - Administrative SupplementR01NS105853 · NINDS · MAYO CLINIC ROCHESTER · PI BRINJIKJI, WALEED · 2018 to 2022
$2.0M
NINDS NIH HHS R01 NS105853
6 · The paper itself

Abstract

backgroundThe presence of an outer shell has been recently described as a common feature of acute ischemic stroke (AIS) thrombi. We performed a systematic review of the current literature on shell genesis, structure, and clinical significance.

methodsFollowing PRISMA guidelines, we searched Ovid Cochrane Central Register of Controlled Trials, Embase, Medline, Scopus, and Web of Science for studies reporting the composition and structure of AIS thrombi and clot analogs. Identified studies were added to Covidence software for primary screening. Two reviewers independently screened titles and abstracts followed by full-text screening.

resultsFrom 1290 identified studies, 10 were included in this review. Studies using histology/immunohistochemistry/immunofluorescence described fibrin, platelets, von Willebrand factor, and neutrophil extracellular traps as the main components of the shell. Scanning electron microscopy demonstrated a dense, compact fibrin/platelet-rich shell, and a core rich in polyhedrocytes. Microfluidics studies identified highly activated P-selectin-positive platelets and fibrin forming the core while secondary agonists adenosine diphosphate and thromboxane, along with loosely packed P-selectin-negative platelets constituted the shell.

conclusionsThe composition, compaction, and integrity of the shell may impact thrombolysis and revascularization outcomes. The preponderance of studies supported this conclusion.

Indexed as

Ischemic StrokeStrokeThrombosisBiologyFibrinHumansP-SelectinFibrinP-Selectinischemic strokeshellsystematic reviewthrombi

Identifiers

PMID37960892
PMCPMC10647960
OpenAlexW4388669170

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.