Evidence map›Paper›PMID 37960308›Full record

ArticleNutrients2023

Deficiency of apoA-IV in Female 129X1/SvJ Mice Leads to Diet-Induced Obesity, Insulin Resistance, and Decreased Energy Expenditure.

Jie Qu, Dong Wu, Chih-Wei Ko, Qi Zhu, Min Liu, Patrick Tso

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Jie QuMedpace Reference Laboratories, LLC, 5365 Medpace Way, Cincinnati, OH 45227, USA.
Dong WuDepartment of General Surgery, Qilu Hospital of Shandong University, Jinan 250012, China.
Chih-Wei KoChroma Medicine, 201 Brookline Ave, Suite 1101, Boston, MA 02215, USA.
Qi ZhuDepartment of Pathology and Laboratory Medicine, Metabolic Diseases Institute, University of Cincinnati, 2180 E Galbraith Road, Cincinnati, OH 45237, USA.
Min LiuDepartment of Pathology and Laboratory Medicine, Metabolic Diseases Institute, University of Cincinnati, 2180 E Galbraith Road, Cincinnati, OH 45237, USA.
Patrick TsoDepartment of Pathology and Laboratory Medicine, Metabolic Diseases Institute, University of Cincinnati, 2180 E Galbraith Road, Cincinnati, OH 45237, USA.
University of Cincinnati · USMedpace (United States) · USQilu Hospital of Shandong University · CN

Funding

Stem Cell/Organoid and Genome Editing CoreP30DK078392 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI Alexander Miethke · 2007 to 2026
$24.4M
LIPID, LIPOPROTEIN, AND GLUCOSE METABOLISM COREU24DK059630 · NIDDK · UNIVERSITY OF CINCINNATI · PI TSO, PATRICK · 2001 to 2015
$12.9M
Role of the GI lymphatic system in hormonal signaling and nutrient metabolismR01DK119135 · NIDDK · UNIVERSITY OF CINCINNATI · PI LIU, MIN, TSO, PATRICK · 2018 to 2022
$3.0M
NIDDK NIH HHS P30 DK078392NIDDK NIH HHS R01 DK119135NIDDK NIH HHS U24 DK059630NIH HHS DK119135 and DK59630
6 · The paper itself

Abstract

Obesity is one of the main risk factors for cardiovascular diseases, type II diabetes, hypertension, and certain cancers. Obesity in women at the reproductive stage adversely affects contraception, fertility, maternal well-being, and the health of their offspring. Being a major protein component in chylomicrons and high-density lipoproteins, apolipoprotein A-IV (apoA-IV) is involved in lipid metabolism, food intake, glucose homeostasis, prevention against atherosclerosis, and platelet aggregation. The goal of the present study is to determine the impact of apoA-IV deficiency on metabolic functions in 129X1/SvJ female mouse strain. After chronic high-fat diet feeding, apoA-IV

Indexed as

Diabetes Mellitus, Type 2Insulin ResistanceAnimalsApolipoproteins ADiet, High-FatEnergy MetabolismFemaleHumansMiceMice, Inbred C57BLMice, Inbred StrainsObesityapolipoprotein A-IVApolipoproteins A129X1/SvJ miceapolipoprotein A-IVobesity

Identifiers

PMID37960308
PMCPMC10650794
OpenAlexW4388233325

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.