ReviewNutrients2023
The Influence of Early Nutrition on Neurodevelopmental Outcomes in Preterm Infants.
Review in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Nutritional Management of Low Birth Weight and Preterm Infants in Low- and Low Middle-Income Countries.Neonatology · 2025Pooled it
- Nutritional status of school-going adolescent girls is associated with their cognitive function but not academic performance: insights from Ten2Twenty-Ghana baseline study.Nutrition journal · 2026Article
- The Earliest Impressions: A Systematic Review of Early-Life Exposures on Brain Structure and Neurodevelopmental Outcomes.bioRxiv : the preprint server for biology · 2026Article
- Relationships of Early Parenteral Nutrition and Human Milk Fortification on the Growth of Neonates With Birth Weights Between 1500 and 1750 g.Journal of paediatrics and child health · 2026Article
- DHA: Nutritional Programming During the First 1000 Days of Life.Nutrients · 2026Review
- Ethnicity and antenatal maternal anxiety: associations with the human milk lipidome in a multi-ethnic Asian cohort.Frontiers in nutrition · 2026Article
- Mineral Profiling of Preterm, Term Breast Milk, and Commercial Infant Formula: Evaluating Nutritional Adequacy for Premature Neonates.Preventive nutrition and food science · 2026Article
- Early parenteral lipid intake supports cerebellar neurometabolism at term-age in preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2025Observational
- The influence of early nutrition intake and clinical factors on the brain development of preterm infants with intrauterine growth restriction.Translational pediatrics · 2025Article
- Improved Growth Velocity Using a New Liquid Human Milk Fortifier in Very Low Birth Weight Infants: A Multicenter, Retrospective Study.American journal of perinatology · 2025Article
- Exclusive human milk diet is associated with lower risk of motor function impairment at three years of corrected age.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Neurological Outcomes in Late Preterm Infants: An Updated Review of Recent Research and Clinical Insights.Diagnostics (Basel, Switzerland) · 2025Review
- Early Optimal Parenteral Nutrition During NICU Stay and Neurodevelopmental Outcomes in Very Preterm Infants: State of the Art.Nutrients · 2025Review
- Influence of oropharyngeal therapy with mother's own milk on the microbiome and metabolome of very preterm infants: a pilot study.Frontiers in nutrition · 2025Article
- Early-life sodium restriction programs autonomic dysfunction and salt sensitivity in male C57BL/6J mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2025Article
- Nutritional Strategies for Preterm Neonates and Preterm Neonates Undergoing Surgery: New Insights for Practice and Wrong Beliefs to Uproot.Nutrients · 2024Review
- Impact of Early Nutrition Interventions on the Growth and Development of Preterm Infants: A Narrative Review.Cureus · 2024Review
- Association between type of feeding at hospital discharge and nutritional status of Brazilian very preterm infants: a multicenter study.Jornal de pediatriaArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Premature infants, given their limited reserves, heightened energy requirements, and susceptibility to nutritional deficits, require specialized care.
aimTo examine the complex interplay between nutrition and neurodevelopment in premature infants, underscoring the critical need for tailored nutritional approaches to support optimal brain growth and function. DATA SOURCES: PubMed and MeSH and keywords: preterm, early nutrition, macronutrients, micronutrients, human milk, human milk oligosaccharides, probiotics AND neurodevelopment or neurodevelopment outcomes. Recent articles were selected according to the authors' judgment of their relevance. Specific nutrients, including macro (amino acids, glucose, and lipids) and micronutrients, play an important role in promoting neurodevelopment. Early and aggressive nutrition has shown promise, as has recognizing glucose as the primary energy source for the developing brain. Long-chain polyunsaturated fatty acids, such as DHA, contribute to brain maturation, while the benefits of human milk, human milk oligosaccharides, and probiotics on neurodevelopment via the gut-brain axis are explored. This intricate interplay between the gut microbiota and the central nervous system highlights human milk oligosaccharides' role in early brain maturation.
conclusionsIndividualized nutritional approaches and comprehensive nutrient strategies are paramount to enhancing neurodevelopment in premature infants, underscoring human milk's potential as the gold standard of nutrition for preterm infants.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.