Trial reportNutrients2023
Perioperative Enteral Immunonutrition Support for the Immune Function and Intestinal Mucosal Barrier in Gastric Cancer Patients Undergoing Gastrectomy: A Prospective Randomized Controlled Study.
Trial report in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Effects of enteral immunonutrition enriched with multiple immunonutrients on clinical outcomes of patients who underwent gastric cancer surgery: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- Pooled it
- Enteral nutrition support in patients with cancer: association of short-term prognosis and medical costs with inflammation.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Trial
- Review
- The effect of immunonutritional support in patients undergoing surgery and adjuvant chemotherapy for lung cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Impact of enhanced recovery after surgery protocol on postoperative complications and hospital stay following laparoscopic distal gastrectomy for gastric cancer.BMC gastroenterology · 2026Article
- Incidence, risk factors, recovery duration, and prognostic implications of gastroparesis following radical distal gastrectomy for gastric cancer: a large retrospective cohort study.International journal of surgery (London, England) · 2026Article
- Precision nutrition in gastric cancer: current advances and future directions.Frontiers in nutrition · 2026Review
- Perioperative nutritional support is associated with attenuated early postoperative albumin decline after gastrectomy for gastric cancer: a retrospective cohort study and machine learning prediction model.Frontiers in medicine · 2026Article
- Effect of Electroacupuncture on Intestinal Mucosal Barrier in IBS-D Rats: Analysis Based on RNA-seq.Combinatorial chemistry & high throughput screening · 2026Article
- Dexmedetomidine enhances anastomotic healing partlyWorld journal of gastroenterology · 2025Article
- Clinical significance of systemic inflammation response index and platelet-lymphocyte ratio in patients with stage I-III gastric cancer.World journal of gastrointestinal surgery · 2025Article
- Prognostic immune nutritional index-based nutritional stratification enhances recovery and survival in gastric cancer: A randomized controlled trial.World journal of clinical oncology · 2025Article
- Serum immune indicators including IgM, IgA, and IgG levels and quality of life of patients with gastrointestinal tumours during chemotherapy.Journal of medical biochemistry · 2025Article
- Perioperative nutritional support in patients undergoing gastrointestinal surgery: Current views with an emphasis on prehabilitation efforts.World journal of gastrointestinal surgery · 2025Article
- Association between postoperative feeding patterns and gastrointestinal function reconstruction after congenital intestinal atresia in neonates.World journal of gastrointestinal surgery · 2025Article
- Effectiveness of nutrition support team-led care on perioperative outcomes in malnourished older adults with gastric cancer.Frontiers in nutrition · 2025Article
- The Impact of Nutritional Management on Postoperative Recovery Outcomes in Prostate Cancer Patients Undergoing Radical Prostatectomy: A Retrospective Study.Journal of multidisciplinary healthcare · 2025Article
- Immunonutrition in Operated-on Gastric Cancer Patients: An Update.Biomedicines · 2024Review
- Enhancing CD4+/CD8+ T cell ratio and accelerating recovery in HNSCC patients through immunonutrition intervention.Discover oncology · 2024Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
objectiveThe impact of perioperative immunonutrition on patients undergoing radical gastrectomy remains undetermined. This study aimed to assess the influence of enteral immunonutrition support on postoperative immune function and intestinal mucosal barrier function following radical gastrectomy, contrasting findings with a control group to furnish evidence for perioperative enteral nutrition support.
methodsIn this prospective randomized trial, 65 patients who underwent radical gastrectomy between June 2022 and June 2023 were included. Participants were allocated to either the study group (receiving enteral immunonutrition) or the control group (not receiving enteral immunonutrition). We compared postoperative rehabilitation and complications between the groups, analyzed the intestinal mucosal barrier function markers on the 3rd and 7th postoperative days, and delved deeper into peripheral blood cell immunity, inflammation, and nutritional indicators.
resultsThe cohort consisted of 30 patients in the study group and 35 in the control group, with no significant differences in demographic attributes between the two groups. On the 3rd postoperative day, the diamine oxidase, D-lactic acid, and endotoxin levels in the study group were significantly lower than those in the control group (
conclusionAdministering perioperative enteral immunonutrition enhances postoperative immune and intestinal mucosal barrier functions in patients undergoing radical gastrectomy. This effect leads to diminished inflammatory responses, a decreased rate of postoperative complications, and accelerated patient recovery.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.