Evidence map›Paper›PMID 37960204›Full record

ReviewNutrients2023

The Role of Gut Microbiota in Gestational Diabetes Mellitus Affecting Intergenerational Glucose Metabolism: Possible Mechanisms and Interventions.

Yaolin Ren, Yuan Zeng, Yifan Wu, Jie Yu, Qian Zhang, Xinhua Xiao

Open access · goldAbstract readReview
In one paragraph

Review in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Yaolin RenKey Laboratory of Endocrinology, Ministry of Health, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
Yuan ZengKey Laboratory of Endocrinology, Ministry of Health, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.ORCID 0009-0002-4414-7488
Yifan WuKey Laboratory of Endocrinology, Ministry of Health, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
Jie YuKey Laboratory of Endocrinology, Ministry of Health, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
Qian ZhangKey Laboratory of Endocrinology, Ministry of Health, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.ORCID 0000-0001-9846-0141
Xinhua XiaoKey Laboratory of Endocrinology, Ministry of Health, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
Chinese Academy of Medical Sciences & Peking Union Medical College · CN

Funding

Beijing Municipal Science & Technology Commission Z201100005520011Beijing Natural Science Foundation 7202163Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences CIFMS2017-I2M-1-008Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences CIFMS2021-I2M-1-002Medical Epigenetics Research Center, Chinese Academy of Medical Sciences 2017PT31036Medical Epigenetics Research Center, Chinese Academy of Medical Sciences 2018PT31021National High Level Hospital Clinical Research Funding 2022-PUMCH-C-019National Key Research and Development Program of China 2016YFA0101002National Key Research and Development Program of China 2018YFC2001100National Key Research and Development Program of China 2021YFC2501700National Natural Science Foundation of China 81170736National Natural Science Foundation of China 81570715National Natural Science Foundation of China 81870545National Natural Science Foundation of China 81870579National Natural Science Foundation of China 82170854Scientific Activities Foundation for Selected Returned Overseas Professionals of Human Resources and Social Security Ministry, Beijing Dongcheng District Outstanding Talent Funding Project 2019DCT-M-05the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences 2017PT32020the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences 2018PT32001
6 · The paper itself

Abstract

The incidence of type 2 diabetes is increasing every year and has become a serious public health problem. In addition to genetic factors, environmental factors in early life development are risk factors for diabetes. There is growing evidence that the gut microbiota plays an important role in glucose metabolism, and the gut microbiota of pregnant women with gestational diabetes mellitus (GDM) differs significantly from that of healthy pregnant women. This article reviews the role of maternal gut microbiota in offspring glucose metabolism. To explore the potential mechanisms by which the gut microbiota affects glucose metabolism in offspring, we summarize clinical studies and experimental animal models that support the hypothesis that the gut microbiota affects glucose metabolism in offspring from dams with GDM and discuss interventions that could improve glucose metabolism in offspring. Given that adverse pregnancy outcomes severely impact the quality of survival, reversing the deleterious effects of abnormal glucose metabolism in offspring through early intervention is important for both mothers and their offspring.

Indexed as

Diabetes, GestationalDiabetes Mellitus, Type 2Gastrointestinal MicrobiomeAnimalsFemaleGlucoseHumansPregnancyRisk FactorsGlucoseDevelopmental Origins of Health and Diseasediabetes mellitusgestational diabetes mellitusgut microbiotaintergenerational effect

Identifiers

PMID37960204
PMCPMC10648599
OpenAlexW4387971561

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.