Evidence map›Paper›PMID 37960146›Full record

ArticleNutrients2023

Drastic Synergy of Lovastatin and

Chih-Jung Yao, Chia-Lun Chang, Ming-Hung Hu, Chien-Huang Liao, Gi-Ming Lai, Tzeon-Jye Chiou, Hsien-Ling Ho, Hui-Ching Kuo, Ya-Yu Yang, Jacqueline Whang-Peng and 1 more

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Chih-Jung YaoDepartment of Medical Education and Research, Wan Fang Hospital, Taipei Medical University, Taipei 11696, Taiwan.
Chia-Lun ChangDepartment of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.
Ming-Hung HuDivision of Hematology and Medical Oncology, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei 11696, Taiwan.ORCID 0000-0002-9923-0281
Chien-Huang LiaoCancer Center, Wan Fang Hospital, Taipei Medical University, Taipei 11696, Taiwan.
Gi-Ming LaiDivision of Hematology and Medical Oncology, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei 11696, Taiwan.
Tzeon-Jye ChiouDivision of Hematology and Medical Oncology, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei 11696, Taiwan.ORCID 0000-0002-0495-3859
Hsien-Ling HoCancer Center, Wan Fang Hospital, Taipei Medical University, Taipei 11696, Taiwan.
Hui-Ching KuoCancer Center, Wan Fang Hospital, Taipei Medical University, Taipei 11696, Taiwan.
Ya-Yu YangNational Institute of Cancer Research, National Health Research Institutes, Miaoli 35053, Taiwan.
Jacqueline Whang-PengDivision of Hematology and Medical Oncology, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei 11696, Taiwan.
Shuang-En ChuangNational Institute of Cancer Research, National Health Research Institutes, Miaoli 35053, Taiwan.
Wan Fang Hospital · TWNational Health Research Institutes · TW

Funding

Health and welfare surcharge of tobacco products, Taiwan MOHW103-TD-B-111-01 and MOHW104-TDU-B-212-124-001National Health Research Institutes, Miaoli, Taiwan CA-111-PP-16Research grant from Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan 110-wf-eva-11
6 · The paper itself

Abstract

Prostate cancer (PC) is the second most frequently diagnosed cancer and the fifth leading cause of cancer-related death in males worldwide. Early-stage PC patients can benefit from surgical, radiation, and hormonal therapies; however, once the tumor transitions to an androgen-refractory state, the efficacy of treatments diminishes considerably. Recently, the exploration of natural products, particularly dietary phytochemicals, has intensified in response to addressing this prevailing medical challenge. In this study, we uncovered a synergistic effect from combinatorial treatment with lovastatin (an active component in red yeast rice) and

Indexed as

Biological ProductsProstatic NeoplasmsAndrogensApoptosisCell Line, TumorCell ProliferationHumansLovastatinMalePC-3 CellsPolyporalesAndrogensBiological ProductsLovastatinAntrodia camphorataAXLlovastatinPC3prostate cancer

Identifiers

PMID37960146
PMCPMC10647293
OpenAlexW4387907356

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.