Evidence map›Paper›PMID 37959862›Full record

ArticleMolecules (Basel, Switzerland)2023

Synthesis of Tetracyclic Spirooxindolepyrrolidine-Engrafted Hydantoin Scaffolds: Crystallographic Analysis, Molecular Docking Studies and Evaluation of Their Antimicrobial, Anti-Inflammatory and Analgesic Activities.

Amani Toumi, Faiza I A Abdella, Sarra Boudriga, Tahani Y A Alanazi, Asma K Alshamari, Ahlam Abdulrahman Alrashdi, Amal Dbeibia, Khaled Hamden, Ismail Daoud, Michael Knorr and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 16 citations in OpenAlex.

  1. Pyrrolidine-Based Antifungal Agents AgainstPharmaceuticals (Basel, Switzerland) · 2026
    Review
  2. Anti-Inflammatory Activity of Cyclic Imide Derivatives.Pharmaceuticals (Basel, Switzerland) · 2026
    Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 5 countries.

Amani ToumiLaboratory of Heterocyclic Chemistry Natural Product and Reactivity (LR11ES39), Department of Chemistry, Faculty of Science of Monastir, University of Monastir, Monastir 5019, Tunisia.
Faiza I A AbdellaDepartment of Chemistry, College of Science, Ha'il University, Ha'il 81451, Saudi Arabia.
Sarra BoudrigaLaboratory of Heterocyclic Chemistry Natural Product and Reactivity (LR11ES39), Department of Chemistry, Faculty of Science of Monastir, University of Monastir, Monastir 5019, Tunisia.
Tahani Y A AlanaziDepartment of Chemistry, College of Science, Ha'il University, Ha'il 81451, Saudi Arabia.
Asma K AlshamariDepartment of Chemistry, College of Science, Ha'il University, Ha'il 81451, Saudi Arabia.
Ahlam Abdulrahman AlrashdiDepartment of Chemistry, College of Science, Ha'il University, Ha'il 81451, Saudi Arabia.
Amal DbeibiaLaboratory of Analysis, Treatment and Valorization of Environmental Pollutants and Products, Faculty of Pharmacy, University of Monastir, Monastir 5019, Tunisia.
Khaled HamdenLaboratory of Bioresources: Integrative Biology and Valorization, Higher Institute of Biotechnology of Monastir, University of Monastir, Monastir 5000, Tunisia.ORCID 0000-0001-5651-3962
Ismail DaoudDepartment of Matter Sciences, University of Mohamed Khider, BP 145 RP, Biskra 07000, Algeria.
Michael KnorrInstitut UTINAM-UMR CNRS 6213, Université de Franche-Comté, 16 Route de Gray, 25030 Besançon, France.ORCID 0000-0002-5647-8084
Jan-Lukas KirchhoffFaculty of Chemistry, Inorganic Chemistry, Technical University Dortmund, Otto-Hahn-Strasse 6, 44227 Dortmund, Germany.ORCID 0000-0003-3897-9114
Carsten StrohmannFaculty of Chemistry, Inorganic Chemistry, Technical University Dortmund, Otto-Hahn-Strasse 6, 44227 Dortmund, Germany.ORCID 0000-0002-4787-2135
University of Ha'il · SAUniversity of Monastir · TNTU Dortmund University · DECentre National de la Recherche Scientifique · FRUniversity of Biskra · DZ

Funding

This research has been funded by the Deputy for Research & Innovation, Ministry of Education through Initiative of Institutional Funding at University of Ha'il-Saudi Arabia through project number RG-23 065 RG-23 065
6 · The paper itself

Abstract

In a sustained search for novel potential drug candidates with multispectrum therapeutic application, a series of novel spirooxindoles was designed and synthesized via regioselective three-component reaction between isatin derivatives, 2-phenylglycine and diverse arylidene-imidazolidine-2,4-diones (Hydantoins). The suggested stereochemistry was ascertained by an X-ray diffraction study and NMR spectroscopy. The resulting tetracyclic heterocycles were screened for their in vitro

Indexed as

Anti-Infective AgentsHydantoinsAnalgesicsAnti-Bacterial AgentsAnticonvulsantsAnti-Inflammatory AgentsAnti-Inflammatory Agents, Non-SteroidalMolecular Docking SimulationMolecular StructureStructure-Activity RelationshipAnalgesicsAnti-Bacterial AgentsAnticonvulsantsAnti-Infective AgentsAnti-Inflammatory AgentsAnti-Inflammatory Agents, Non-SteroidalHydantoinsanalgesicanti-inflammatoryantimicrobialcrystal structurehydantoinmolecular dockingspirooxindoles

Identifiers

PMID37959862
PMCPMC10650415
OpenAlexW4388419553

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.