Evidence map›Paper›PMID 37959793›Full record

ArticleMolecules (Basel, Switzerland)2023

Large Subunit of the Human Herpes Simplex Virus Terminase as a Promising Target in Design of Anti-Herpesvirus Agents.

Victor P Krasnov, Valeriya L Andronova, Alexander V Belyavsky, Sophia S Borisevich, George A Galegov, Oleg F Kandarakov, Dmitry A Gruzdev, Olga A Vozdvizhenskaya, Galina L Levit

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Sumac Polyphenols as Pan-Herpesvirus Inhibitors.International journal of molecular sciences · 2025
    Article
  3. Combined Effect of Basic Antiherpetic Drugs with a New Inhibitor of the Terminase Complex of Herpes Simplex Virus Type 1 in Vero Cell Cultures.Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Victor P KrasnovPostovsky Institute of Organic Synthesis, Russian Academy of Sciences (Ural Branch), Ekaterinburg 620108, Russia.ORCID 0000-0003-1411-6218
Valeriya L AndronovaGamaleya National Research Center for Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow 123098, Russia.
Alexander V BelyavskyEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow 119991, Russia.ORCID 0000-0003-4337-4128
Sophia S BorisevichUfa Institute of Chemistry, Russian Academy of Sciences, Ufa 450078, Russia.ORCID 0000-0001-8481-0470
George A GalegovGamaleya National Research Center for Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow 123098, Russia.
Oleg F KandarakovEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow 119991, Russia.
Dmitry A GruzdevPostovsky Institute of Organic Synthesis, Russian Academy of Sciences (Ural Branch), Ekaterinburg 620108, Russia.ORCID 0000-0002-7384-1797
Olga A VozdvizhenskayaPostovsky Institute of Organic Synthesis, Russian Academy of Sciences (Ural Branch), Ekaterinburg 620108, Russia.
Galina L LevitPostovsky Institute of Organic Synthesis, Russian Academy of Sciences (Ural Branch), Ekaterinburg 620108, Russia.ORCID 0000-0002-0964-9311
Institute of Organic Synthesis · RUEngelhardt Institute of Molecular Biology · RUMinistry of Health of the Russian Federation · RUUfa Institute of Chemistry · RU

Funding

Russian Science Foundation 19-13-00231-P
6 · The paper itself

Abstract

Herpes simplex virus type 1 (HSV-1) is an extremely widespread pathogen characterized by recurrent infections. HSV-1 most commonly causes painful blisters or sores around the mouth or on the genitals, but it can also cause keratitis or, rarely, encephalitis. First-line and second-line antiviral drugs used to treat HSV infections, acyclovir and related compounds, as well as foscarnet and cidofovir, selectively inhibit herpesvirus DNA polymerase (DNA-pol). It has been previously found that (

Indexed as

Herpes SimplexHerpesvirus 1, HumanAcyclovirAntiviral AgentsDNA-Directed DNA PolymeraseDrug Resistance, ViralEndodeoxyribonucleasesHumansAcyclovirAntiviral AgentsDNA-Directed DNA PolymeraseEndodeoxyribonucleasesterminasedrug resistanceherpes simplex virushigh-throughput sequencingin vitro antiviral activitymolecular dockingmolecular dynamic simulationsmutation analysis

Identifiers

PMID37959793
PMCPMC10649544
OpenAlexW4388084962

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.