Evidence map›Paper›PMID 37959786›Full record

ArticleMolecules (Basel, Switzerland)2023

Exposure Assessment of Essential and Potentially Toxic Metals in Wheat-Based Sweets for Human Consumption: Multivariate Analysis and Risk Evaluation Studies.

Mahmood Ahmed, Syed Salman Shafqat, Amna Javed, Mudassar Sanaullah, Abdul Shakoor, Muhammad Imtiaz Shafiq, Syeda Kiran Shahzadi, Tanveer A Wani, Seema Zargar

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mahmood AhmedDepartment of Chemistry, Division of Science and Technology, University of Education, College Road, Lahore 54770, Pakistan.ORCID 0000-0002-2285-7406
Syed Salman ShafqatDepartment of Chemistry, Division of Science and Technology, University of Education, College Road, Lahore 54770, Pakistan.ORCID 0000-0001-6961-3065
Amna JavedDepartment of Chemistry, Division of Science and Technology, University of Education, College Road, Lahore 54770, Pakistan.
Mudassar SanaullahDepartment of Chemistry, Division of Science and Technology, University of Education, College Road, Lahore 54770, Pakistan.ORCID 0009-0001-0168-0234
Abdul ShakoorCSH Pharmaceuticals (Pvt.) Ltd., Ferozepur Road, Lahore 54000, Pakistan.
Muhammad Imtiaz ShafiqSchool of Chemistry, University of the Punjab, Lahore 54590, Pakistan.
Syeda Kiran ShahzadiDepartment of Physiology, Faculty of Medicine and Health Sciences, McGill University, Montreal, QC H3A 0G4, Canada.
Tanveer A WaniDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.ORCID 0009-0008-3498-4112
Seema ZargarDepartment of Biochemistry, College of Science, King Saud University, P.O. Box 222452, Riyadh 11451, Saudi Arabia.ORCID 0000-0002-5622-0841

Funding

King Saud University, Riyadh Saudi Arabia RSP2023R357
6 · The paper itself

Abstract

In recent years, there has been a growing concern about the negative impact of unforeseen contaminants such as metals in commonly consumed food items, which pose a threat to human well-being. Therefore, it is of utmost importance to evaluate the levels of these contaminants to guarantee the safe consumption of these food items. The goal of the current research is to determine the levels of essential (EMs: Mg, Ca, Mn, Fe, Co, Cu, and Zn) and potentially toxic metals (PTMs: Al, Cr, Ni, As, Cd, and Pb) in various brands of wheat-based sweets. One hundred samples were collected and analysed via flame atomic absorption spectrometry (FAAS) and inductively coupled plasma-optical emission spectrometry (ICP-OES). Also, the current study was to investigate the distribution, correlation, and multivariate analysis of 13 metals (Mg, Ca, Mn, Fe, Co, Cu, Zn, Al, Cr, Ni, As, Cd, and Pb). Hierarchical cluster analysis (HCA) and principal component analysis (PCA) were used to interpret the metals' association. The concentration (mg/kg) ranges of EMs were, in order, Mg (12.70-65.67), Ca (24.02-209.12), Mn (1.32-9.61), Fe (4.55-111.23), Co (0.32-8.94), Cu (2.12-8.61), and Zn (2.60-19.36), while the concentration (mg/kg) ranges of PTMs were, in order, Al (0.32-0.87), Cr (0.17-5.74), Ni (0.36-1.54), Cd (0.16-0.56), and Pb (0.14-0.92), and As was not detected in any sample under investigation. The HCA data revealed that Co, Al, and Ni form clusters with other metals. Sweets are prepared at high temperatures, and the elevated temperatures can increase the likelihood of Ni and Al leaching from stainless steel. Tolerable dietary intake (TDI) values for Ni were higher than the values established by the European Food Safety Authority (EFSA). The CR value found for the Ni and Cr was at the threshold level of cancer risk, if an amount of 25 g were to be used over a lifetime. In a nutshell, this study highlights the monitoring of EM and PTM levels in wheat-based sweets, and from a food safety perspective, the study is important for consumers of wheat-based sweets.

Indexed as

Metals, HeavyCadmiumEnvironmental MonitoringHeavy Metal PoisoningHumansLeadMultivariate AnalysisRisk AssessmentTriticumCadmiumLeadMetals, Heavychemometric approachdaily intakefood safetyhuman health riskmetal toxicity

Identifiers

PMID37959786
PMCPMC10650165

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.