Evidence map›Paper›PMID 37959779›Full record

ArticleMolecules (Basel, Switzerland)2023

Solubility and Pharmacokinetic Profile Improvement of Griseofulvin through Supercritical Carbon Dioxide-Assisted Complexation with HP-

Yili Ding, Wutong Cui, Zhiyuan Zhang, Yanzhi Ma, Charles Ding, Yikai Lin, Zhe Xu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yili DingCollege of Science and Technology, Wenzhou-Kean University, Wenzhou 325060, China.
Wutong CuiLife Science Department, Foshan University, Foshan 528231, China.
Zhiyuan ZhangLife Science Department, Foshan University, Foshan 528231, China.
Yanzhi MaLife Science Department, Foshan University, Foshan 528231, China.
Charles DingKeck School of Medicine of USC, University of Southern California, Los Angeles, CA 90089-1149, USA.
Yikai LinLife Science Department, Foshan University, Foshan 528231, China.
Zhe XuCollege of Science and Technology, Wenzhou-Kean University, Wenzhou 325060, China.

Funding

Innovation and Entrepreneurship Team Project 201804300016
6 · The paper itself

Abstract

Since griseofulvin was marketed as a non-polyene antifungal antibiotic drug in 1958, its poor water solubility has been an issue for its wide applications, and over the last sixty years, many attempts have been made to increase its water solubility; however, a significant result has yet to be achieved. Through supercritical carbon dioxide-assisted cyclodextrin complexation with the addition of a trace amount of water-soluble polymer surfactant, the griseofulvin inclusion complex with HP-

Indexed as

gamma-CyclodextrinsGriseofulvin2-Hydroxypropyl-beta-cyclodextrinAnimalsCarbon DioxideDogsSolubilityWater2-Hydroxypropyl-beta-cyclodextrinCarbon Dioxidegamma-CyclodextrinsGriseofulvinWatergriseofulvinHP-γ-cyclodextrininclusion complexin vitro and in vivo PK studypreparationwater solubility

Identifiers

PMID37959779
PMCPMC10650103

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.