Evidence map›Paper›PMID 37959771›Full record

ReviewMolecules (Basel, Switzerland)2023

Recent Advances in the Synthesis and Antioxidant Activity of Low Molecular Mass Organoselenium Molecules.

João M Anghinoni, Paloma T Birmann, Marcia J da Rocha, Caroline S Gomes, Michael J Davies, César A Brüning, Lucielli Savegnago, Eder J Lenardão

Abstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Wound Healing Potential of Selenium and Nanoselenium.Biological trace element research · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Synthesis of 2-Aryl-3-(organoselanyl)-4The Journal of organic chemistry · 2025
    Article
  7. Review
  8. Review
  9. Synthesis of Selenium-DecoratedThe Journal of organic chemistry · 2024
    Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

João M AnghinoniLaboratory of Clean Organic Synthesis (LASOL), Center of Chemical, Pharmaceutical and Food Sciences (CCQFA), Federal University of Pelotas (UFPel), P.O. Box 354, Pelotas 96010-900, RS, Brazil.ORCID 0000-0001-5893-287X
Paloma T BirmannNeurobiotechnology Research Group (GPN), Federal University of Pelotas (UFPel), P.O. Box 354, Pelotas 96010-900, RS, Brazil.
Marcia J da RochaLaboratory of Biochemistry and Molecular Neuropharmacology (LABIONEM), Center of Chemical, Pharmaceutical and Food Sciences (CCQFA), Federal University of Pelotas (UFPel), P.O. Box 354, Pelotas 96010-900, RS, Brazil.
Caroline S GomesLaboratory of Clean Organic Synthesis (LASOL), Center of Chemical, Pharmaceutical and Food Sciences (CCQFA), Federal University of Pelotas (UFPel), P.O. Box 354, Pelotas 96010-900, RS, Brazil.ORCID 0009-0005-0363-1726
Michael J DaviesDepartment of Biomedical Sciences, Panum Institute, University of Copenhagen, Building 12.6, Blegdamsvej 3, 2200 Copenhagen, Denmark.ORCID 0000-0002-5196-6919
César A BrüningLaboratory of Biochemistry and Molecular Neuropharmacology (LABIONEM), Center of Chemical, Pharmaceutical and Food Sciences (CCQFA), Federal University of Pelotas (UFPel), P.O. Box 354, Pelotas 96010-900, RS, Brazil.ORCID 0000-0003-0814-0203
Lucielli SavegnagoNeurobiotechnology Research Group (GPN), Federal University of Pelotas (UFPel), P.O. Box 354, Pelotas 96010-900, RS, Brazil.
Eder J LenardãoLaboratory of Clean Organic Synthesis (LASOL), Center of Chemical, Pharmaceutical and Food Sciences (CCQFA), Federal University of Pelotas (UFPel), P.O. Box 354, Pelotas 96010-900, RS, Brazil.ORCID 0000-0001-7920-3289

Funding

Coordenação de Aperfeicoamento de Pessoal de Nível Superior 001Financiadora de Estudos e Projetos CT-INFRAFundação de Amparo à Pesquisa do Estado do Rio Grande do Sul 21/2551-0002094-6National Council for Scientific and Technological Development 422645/2021-4Novo Nordisk Foundation NNF20SA0064214
6 · The paper itself

Abstract

Selenium is an essential trace element in living organisms, and is present in selenoenzymes with antioxidant activity, like glutathione peroxidase (GPx) and thioredoxin reductase (TrxR). The search for small selenium-containing molecules that mimic selenoenzymes is a strong field of research in organic and medicinal chemistry. In this review, we review the synthesis and bioassays of new and known organoselenium compounds with antioxidant activity, covering the last five years. A detailed description of the synthetic procedures and the performed in vitro and in vivo bioassays is presented, highlighting the most active compounds in each series.

Indexed as

Organoselenium CompoundsSeleniumTrace ElementsAntioxidantsGlutathione PeroxidaseOxidative StressThioredoxin-Disulfide ReductaseAntioxidantsGlutathione PeroxidaseOrganoselenium CompoundsSeleniumThioredoxin-Disulfide ReductaseTrace ElementsABTSantioxidantcatalaseDPPHFRAPGPx-likelipid peroxidationorganoseleniumSOD

Identifiers

PMID37959771
PMCPMC10649092

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.