Evidence map›Paper›PMID 37959764›Full record

ArticleMolecules (Basel, Switzerland)2023

Stable Isotope Labeling-Based Nontargeted Strategy for Characterization of the In Vitro Metabolic Profile of a Novel Doping BPC-157 in Doping Control by UHPLC-HRMS.

Tian Tian, Jing Jing, Yuanyuan Li, Yang Wang, Xiaojun Deng, Yuanhong Shan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Tian TianShanghai Anti-Doping Laboratory, Shanghai University of Sport, Shanghai 200438, China.ORCID 0009-0001-6410-5974
Jing JingShanghai Anti-Doping Laboratory, Shanghai University of Sport, Shanghai 200438, China.
Yuanyuan LiShanghai Anti-Doping Laboratory, Shanghai University of Sport, Shanghai 200438, China.
Yang WangShanghai Anti-Doping Laboratory, Shanghai University of Sport, Shanghai 200438, China.
Xiaojun DengShanghai Anti-Doping Laboratory, Shanghai University of Sport, Shanghai 200438, China.ORCID 0000-0002-1051-2507
Yuanhong ShanShanghai Anti-Doping Laboratory, Shanghai University of Sport, Shanghai 200438, China.
Shanghai University of Sport · CN

Funding

Ministry of Science and Technology of the People's Republic of China 2020YFF0304501Research Project of Shanghai University of Sport 2023STD018Research Project of Shanghai University of Sport 2023STD026
6 · The paper itself

Abstract

Traditional strategies for the metabolic profiling of doping are limited by the unpredictable metabolic pathways and the numerous proportions of background and chemical noise that lead to inadequate metabolism knowledge, thereby affecting the selection of optimal detection targets. Thus, a stable isotope labeling-based nontargeted strategy combined with ultra-high-performance liquid chromatography-high-resolution mass spectrometry (UHPLC-HRMS) was first proposed for the effective and rapid metabolism analysis of small-molecule doping agents and demonstrated via its application to a novel doping BPC-157. Using

Indexed as

MetabolomeChromatography, High Pressure LiquidHumansIsotope LabelingMass SpectrometryPeptide FragmentsProteinsBPC 157Peptide FragmentsProteinsBPC-157doping controlmetabolic profilestable isotope labelingUHPLC-HRMS

Identifiers

PMID37959764
PMCPMC10650108
OpenAlexW4388105316

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.