Synthesis and Reactivity of Fluorinated Dithiocarboxylates to Prepare Thioamides-Effective Access to a 4-Styrenylthioamide-Cinchona Alkaloid Monomer.

Aimar Gonzalo-Barquero, Bénédicte Lepoittevin, Jacques Rouden, Jérôme Baudoux

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Aimar Gonzalo-BarqueroLaboratoire de Chimie Moléculaire et Thioorganique, UMR 6507, ENSICAEN, UNICAEN, CNRS, Normandie Université, 6 Bd du Maréchal Juin, 14050 Caen, France.

Bénédicte LepoittevinLaboratoire de Chimie Moléculaire et Thioorganique, UMR 6507, ENSICAEN, UNICAEN, CNRS, Normandie Université, 6 Bd du Maréchal Juin, 14050 Caen, France.ORCID 0000-0002-2210-2337

Jacques RoudenLaboratoire de Chimie Moléculaire et Thioorganique, UMR 6507, ENSICAEN, UNICAEN, CNRS, Normandie Université, 6 Bd du Maréchal Juin, 14050 Caen, France.

Jérôme BaudouxLaboratoire de Chimie Moléculaire et Thioorganique, UMR 6507, ENSICAEN, UNICAEN, CNRS, Normandie Université, 6 Bd du Maréchal Juin, 14050 Caen, France.ORCID 0000-0002-5354-4066

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A simple and rapid access to fluorinated dithioesters was developed by a one-pot sequence corresponding to a Grignard reaction-Mitsunobu type substitution. These activated dithioesters have shown excellent reactivity in an aminolysis reaction from simple or more complex primary amines such as cinchona alkaloids. A stoichiometric amount of amine was sufficient to prepare various thioamides, including a 4-styrenylthioamide cinchonidine monomer, under environmentally friendly conditions, at room temperature, and in a very short time.

Indexed as

dithiocarboxylic acidsdithioestersgrignard reagentsmitsunobu reactionthioamides

Identifiers

PMID37959753

DOI10.3390/molecules28217333

PMCPMC10649591

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.