Evidence map›Paper›PMID 37959718›Full record

ArticleMolecules (Basel, Switzerland)2023

Anti-Inflammatory Activity of 1,6,7-Trihydroxy-2-(1,1-dimethyl-2-propenyl)-3-methoxyxanthone Isolated from

Wonmin Ko, Jong-Suep Baek, Zhiming Liu, Linsha Dong, Nayeon Kim, Hwan Lee, Chi-Su Yoon, Na Young Kim, Sam Cheol Kim, Dong-Sung Lee

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Anti-Neuroinflammatory Effects of Compounds Isolated fromMolecules (Basel, Switzerland) · 2025
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Wonmin KoCollege of Pharmacy, Wonkwang University, 460, Iksan-daero, Iksan-si 54538, Republic of Korea.
Jong-Suep BaekDepartment of Bio-Health Convergence, Kangwon National University, 1, Kangwondaehak-gil, Chuncheon-si 24341, Republic of Korea.ORCID 0000-0002-0535-345X
Zhiming LiuCollege of Pharmacy, Chosun University, 309, Pilmun-daero, Dong-gu, Gwangju 61452, Republic of Korea.
Linsha DongCollege of Pharmacy, Chosun University, 309, Pilmun-daero, Dong-gu, Gwangju 61452, Republic of Korea.
Nayeon KimCollege of Pharmacy, Chosun University, 309, Pilmun-daero, Dong-gu, Gwangju 61452, Republic of Korea.
Hwan LeeCollege of Pharmacy, Chosun University, 309, Pilmun-daero, Dong-gu, Gwangju 61452, Republic of Korea.ORCID 0000-0001-5015-5949
Chi-Su YoonCollege of Pharmacy, Wonkwang University, 460, Iksan-daero, Iksan-si 54538, Republic of Korea.
Na Young KimPathology Division, National Institute of Fisheries Science, 216, Gijanghaean-ro, Gijang-eup, Gijang-gun, Busan 46083, Republic of Korea.
Sam Cheol KimDepartment of Family Practice and Community Medicine, Chosun University College of Medicine, 309, Pilmun-daero, Dong-gu, Gwangju 61452, Republic of Korea.
Dong-Sung LeeCollege of Pharmacy, Chosun University, 309, Pilmun-daero, Dong-gu, Gwangju 61452, Republic of Korea.ORCID 0000-0002-9234-7567
Chosun University · KRWonkwang University · KRKangwon National University · KR

Funding

This research was supported by a grant from the National Institute of Fisheries Science grant number R2023053This research was supported by a research fund from Chosun University in 2021 K207334004
6 · The paper itself

Abstract

Neuroinflammation activated by microglia affects inflammatory pain development. This study aimed to explore the anti-inflammatory properties and mechanisms of 1,6,7-trihydroxy-2-(1,1-dimethyl-2-propenyl)-3-methoxyxanthone (THMX) from

Indexed as

MoraceaeNF-kappa BAnti-Inflammatory AgentsCyclooxygenase 2Interleukin-6LipopolysaccharidesMicrogliaMitogen-Activated Protein KinasesNitric OxideNitric Oxide Synthase Type IIPainSignal TransductionXanthones1,6,7-trihydroxy-2-(1,1-dimethyl-2-propenyl)-3-methoxyxanthoneAnti-Inflammatory AgentsCyclooxygenase 2Interleukin-6LipopolysaccharidesMitogen-Activated Protein KinasesNF-kappa BNitric OxideNitric Oxide Synthase Type IIXanthones1,6,7-Trihydroxy-2-(1,1-dimethyl-2-propenyl)-3-methoxyxanthonemouse macrophage RAW 264.7mouse microglia BV2

Identifiers

PMID37959718
PMCPMC10650866
OpenAlexW4387976800

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.