Evidence map›Paper›PMID 37959715›Full record

ArticleMolecules (Basel, Switzerland)2023

The Use of Cyclodextrin Inclusion Complexes to Increase the Solubility and Pharmacokinetic Profile of Albendazole.

Yili Ding, Zhiyuan Zhang, Charles Ding, Shufeng Xu, Zhe Xu

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Yili DingCollege of Science and Technology, Wenzhou-Kean University, Wenzhou 325000, China.
Zhiyuan ZhangLife Science Department, Foshan University, Foshan 528000, China.
Charles DingKeck School of Medicine of USC, Los Angeles, CA 90089, USA.
Shufeng XuLife Science Department, Foshan University, Foshan 528000, China.
Zhe XuCollege of Science and Technology, Wenzhou-Kean University, Wenzhou 325000, China.
Foshan University · CNKean University · USKeck Hospital of USC · USWenzhou-Kean University · CN

Funding

Innovation and Entrepreneurship Team Project 201804300016
6 · The paper itself

Abstract

Albendazole is the preferred deworming drug and has strong insecticidal effects on human and animal helminth parasites, showing remarkable activity against hepatocellular carcinoma and colorectal cancer cells. However, it is classified as being in class II in the Biopharmaceutics Classification System due to its poor water solubility (0.2 mg/L) and high permeability, which make the clinical application of albendazole impractical. Through complexation with methyl-

Indexed as

AnthelminticsCyclodextrinsAlbendazoleAnimalsHumansSolubilityWaterAlbendazoleAnthelminticsCyclodextrinsWateralbendazoleinclusion complexin vitro and in vivo PK studymethyl-β-cyclodextrinwater solubility

Identifiers

PMID37959715
PMCPMC10648351
OpenAlexW4387976961

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.