The Influence of Chirality on the β-Amino-Acid Naphthalenediimides/G-Quadruplex DNA Interaction.

Samuel R Clowes, Yusuf Ali, Olivia R Astley, Dora M Răsădean, G Dan Pantoş

Open access · goldAbstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

0.2field-weighted citation impact, top 40% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Samuel R ClowesDepartment of Chemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK.ORCID 0000-0003-4675-2980

Yusuf AliDepartment of Chemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK.

Olivia R AstleyDepartment of Chemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK.

Dora M RăsădeanDepartment of Chemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK.

G Dan PantoşDepartment of Chemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK.ORCID 0000-0003-2200-550X

University of Bath · GB

Funding

Engineering and Physical Sciences Research Council DTA for SRC & DMR

6 · The paper itself

Abstract

G-quadruplexes (G4s) have been identified as a potential alternative chemotherapy target. A series of eight β-amino acid derived naphthalenediimides (NDI) were screened against a series of oncogenic G4 sequences: c-KIT1, h-TELO, and TBA. Three sets of enantiomers were investigated to further our understanding of the effect of point chirality on G4 stabilisation. Enantioselective binding behaviour was observed with both c-KIT1 and h-TELO. Docking studies using GNINA and UV-vis titrations were employed to better understand this selective binding behaviour.

Indexed as

G-QuadruplexesAmino AcidsCircular DichroismDNAImidesNaphthalenesAmino AcidsDNAImidesnaphthalenediimideNaphthaleneschiral recognitioncircular dichroismdockingenantioselectivityG-quadruplex DNA

Identifiers

PMID37959711

DOI10.3390/molecules28217291

PMCPMC10647805

OpenAlexW4387976231

What OpenQuestion holds

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LicenceCC BY

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.