Evidence map›Paper›PMID 37959672›Full record

ArticleMolecules (Basel, Switzerland)2023

Nanoparticles of a Pyrazolo-Pyridazine Derivative as Potential EGFR and CDK-2 Inhibitors: Design, Structure Determination, Anticancer Evaluation and In Silico Studies.

Heba E Hashem, Abd El-Galil E Amr, Abdulrahman A Almehizia, Ahmed M Naglah, Benson M Kariuki, Heba A Eassa, Eman S Nossier

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Design, synthesis, andRSC advances · 2025
    Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Synthesis,Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 4 countries.

Heba E HashemDepartment of Chemistry, Faculty of Women, Ain Shams University, Cairo 11757, Egypt.ORCID 0000-0002-9324-4404
Abd El-Galil E AmrApplied Organic Chemistry Department, National Research Center, Cairo 12622, Egypt.ORCID 0000-0002-1338-706X
Abdulrahman A AlmehiziaDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.ORCID 0000-0001-8711-3873
Ahmed M NaglahDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.ORCID 0000-0003-4377-5239
Benson M KariukiSchool of Chemistry, Cardiff University, Main Building, Park Place, Cardiff CF10 3AT, UK.ORCID 0000-0002-8658-3897
Heba A EassaDepartment of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo 11754, Egypt.ORCID 0000-0001-8888-3749
Eman S NossierDepartment of Pharmaceutical Medicinal Chemistry and Drug Design, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo 11754, Egypt.ORCID 0000-0001-6159-5333
Al-Azhar University · EGKing Saud University · SAAin Shams University · EGCardiff University · GBNational Water Research Center · EG

Funding

King Saud University, Riyadh, Saudi Arabia through Researchers Supporting RSPD2023R852
6 · The paper itself

Abstract

The strategic planning of this study is based upon using the nanoformulation method to prepare nanoparticles

Indexed as

Antineoplastic AgentsNanoparticlesPyridazinesAminesCell Line, TumorCell ProliferationDrug Screening Assays, AntitumorErbB ReceptorsHumansMolecular Docking SimulationMolecular StructureProtein Kinase InhibitorsStructure-Activity RelationshipAminesAntineoplastic AgentsEGFR protein, humanErbB ReceptorsProtein Kinase InhibitorsPyridazinesADME analysiscytotoxicitydocking simulationEGFR and CDK-2/cyclin A2 inhibitionnanoparticlespyrazolo[3,4-c]pyridazine

Identifiers

PMID37959672
PMCPMC10648062
OpenAlexW4387937880

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.