ArticleJournal of clinical medicine2023
Optically Guided High-Frequency Ultrasound to Differentiate High-Risk Basal Cell Carcinoma Subtypes: A Single-Centre Prospective Study.
Article in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 18 citations in OpenAlex.
- Reflectance confocal microscopy detects distinct features of field damage in chronically UV-irradiated SKH1 mouse skin.JID innovations : skin science from molecules to population health · 2026Article
- Cost and cost-effectiveness of Mohs micrographic surgery versus conventional excision for nonmelanoma skin cancer: A scoping review.JAAD international · 2026Review
- Surgical Outcomes of Nonmelanoma Skin Cancer Managed with Systematic Preoperative Reflectance Confocal Microscopy-Guided Margin Assessment: A Retrospective Cohort Study Comparing Wide Local Excision and Mohs Micrographic Surgery.Diagnostics (Basel, Switzerland) · 2026Article
- Characterization of dermatofibromas and epidermoid cysts using dermoscopy-guided high-frequency ultrasound imaging.Journal of ultrasound · 2026Article
- Dermoscopy-guided high-frequency ultrasound: Principles and applications in dermatology.JID innovations : skin science from molecules to population health · 2026Article
- Efficacy of 4% 5-Fluorouracil Cream in the Treatment of Actinic Keratoses: A Single-Center Experience.Journal of clinical medicine · 2026Article
- Photobleaching-based autofluorescence mapping reveals distinct patterns in sporadic basal cell carcinoma, nevoid basal cell carcinoma syndrome-associated basal cell carcinoma and squamous cell carcinoma.Frontiers in medicine · 2026Article
- Real-time LC-OCT monitoring of scalp hypertrophic actinic keratosis clearance following cryotherapy, laser, and 5-fluorouracil therapy.Frontiers in medicine · 2026Article
- Ultra-High-Frequency Ultrasound of Melanoma Excision Scars for Detection of Clinically Occult Local Recurrence: A Single-Center Retrospective Study.Clinical, cosmetic and investigational dermatology · 2026Article
- FDA and EMA-approved noninvasive imaging techniques for basal cell carcinoma subtyping: A systematic review.JAAD international · 2025Review
- Novel imaging techniques for tumor margin detection in basal cell carcinoma: a systematic scoping review of FDA and EMA-approved imaging modalities.International journal of dermatology · 2025Article
- High-Frequency and Ultra-High-Frequency Ultrasound in Dermatologic Diseases and Aesthetic Medicine.Medicina (Kaunas, Lithuania) · 2025Review
- Anaphylaxis with Elevated Procalcitonin Mimicking Sepsis: A Literature Review and Report of Two Cases.Journal of clinical medicine · 2025Review
- One-Stop Shop: Diagnosis and Treatment of Basal Cell Carcinoma in One Step.Journal of clinical medicine · 2024Review
- Diagnosis of Skin Cancer: From the Researcher Bench to the Patient's Bedside.Journal of clinical medicine · 2024Article
- Article
Corrections and comments
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Authors and funding
15 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundBasal cell carcinoma (BCC) is the most common type of skin cancer in the Caucasian population. Currently, invasive biopsy is the only way of establishing the histological subtype (HST) that determines the treatment options. Our study aimed to evaluate whether optically guided high-frequency ultrasound (OG-HFUS) imaging could differentiate aggressive HST BCCs from low-risk tumors.
methodsWe conducted prospective clinical and dermoscopic examinations of BCCs, followed by 33 MHz OG-HFUS imaging, surgical excision, and a histological analysis. We enrolled 75 patients with 78 BCCs. In total, 63 BCCs were utilized to establish a novel OG-HFUS risk classification algorithm, while 15 were employed for the validation of this algorithm. The mean age of the patients was 72.9 ± 11.2 years. Histology identified 16 lesions as aggressive HST (infiltrative or micronodular subtypes) and 47 as low-risk HST (superficial or nodular subtypes). To assess the data, we used a one-sided Fisher's exact test for a categorical analysis and a Receiver Operating Characteristic (ROC) curve analysis to evaluate the diagnostic accuracy.
resultsOG-HFUS distinguished aggressive BCC HSTs by their irregular shape (
conclusionsOur study shows that OG-HFUS can identify aggressive BCC HSTs based on easily identifiable morphological parameters, supporting early therapeutic decision making.
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Registered trials
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