Evidence map›Paper›PMID 37959223›Full record

ReviewJournal of clinical medicine2023

Robot-Assisted Radical Prostatectomy in Renal Transplant Recipients: A Systematic Review.

Alberto Piana, Alessio Pecoraro, Flavio Sidoti, Enrico Checcucci, Muhammet İrfan Dönmez, Thomas Prudhomme, Beatriz Bañuelos Marco, Alicia López Abad, Riccardo Campi, Romain Boissier and 5 more

Open access · goldAbstract readReview
In one paragraph

Review in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 10 institutions in 4 countries.

Alberto PianaDepartment of Urology, University of Turin, 10043 Turin, Italy.ORCID 0000-0001-9247-7938
Alessio PecoraroDepartment of Experimental and Clinical Medicine, University of Florence, 50134 Florence, Italy.
Flavio SidotiDepartment of Urology, Romolo Hospital, 88821 Rocca di Neto, Italy.
Enrico CheccucciDepartment of Surgery, Candiolo Cancer Institute FPO-IRCCS, Candiolo, 10060 Turin, Italy.ORCID 0000-0001-7901-5608
Muhammet İrfan DönmezDepartment of Urology, İstanbul Faculty of Medicine, İstanbul University, 34093 İstanbul, Turkey.ORCID 0000-0002-2828-7942
Thomas PrudhommeDepartment of Urology, Kidney Transplantation and Andrology, Toulouse Rangueil University Hospital, 31400 Toulouse, France.ORCID 0000-0003-3601-9339
Beatriz Bañuelos MarcoDivision Renal Transplantation and Reconstructive Urology, Hospital Universitario El Clínico San Carlos, 28040 Madrid, Spain.ORCID 0000-0002-9333-9358
Alicia López AbadDepartment of Experimental and Clinical Medicine, University of Florence, 50134 Florence, Italy.ORCID 0000-0003-1190-2694
Riccardo CampiDepartment of Experimental and Clinical Medicine, University of Florence, 50134 Florence, Italy.ORCID 0000-0001-5237-0888
Romain BoissierDepartment of Urology and Renal Transplantation, La Conception University Hospital, 13005 Marseille, France.
Michele Di DioDivision of Urology, Department of Surgery, Annunziata Hospital, 87100 Cosenza, Italy.
Francesco PorpigliaDepartment of Urology, University of Turin, 10043 Turin, Italy.
Alberto BredaUnit of Uro-oncology and Kidney Transplant, Department of Urology, Puigvert Foundation, Universitat Autònoma de Barcelona (UAB), 08025 Barcelona, Spain.
Angelo TerritoUnit of Uro-oncology and Kidney Transplant, Department of Urology, Puigvert Foundation, Universitat Autònoma de Barcelona (UAB), 08025 Barcelona, Spain.
EAU Young Academic Urologists (YAU) Working Group on Kidney Transplantation
Universitat Autònoma de Barcelona · ESUniversity of Florence · ITUniversity of Turin · ITCandiolo Cancer Institute · ITHôpital de la Conception · FRHôpital Rangueil · FRHospital Clínico San Carlos · ESHospital Universitario Virgen de la Arrixaca · ESIstanbul University · TROspedale Annunziata di Cosenza · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Robot-assisted radical prostatectomy (RARP) has been shown to achieve excellent oncological outcomes with a low rate of complications in patients with prostate cancer. However, data on RARP in renal transplant recipients (RT) are dispersed. A literature search was conducted through April 2023 using PubMed/Medline, Embase and Web of Science databases. The primary aim was to evaluate the safety, oncologic and clinical outcomes of RARP in RT recipients. The secondary aim was to identify surgical technique modifications required to avoid iatrogenic damage to the transplanted kidney. A total of 18 studies comprising 186 patients met the inclusion criteria. Age at the time of treatment ranged 43-79 years. Biopsy results showed a high prevalence of low- and intermediate-risk disease. Operative time ranged between 108.3 and 400 mins, while estimated blood loss ranged from 30 to 630 mL. Length of hospital stay ranged from 3 to 6 days whereas duration of catheterization was between 5 and 18 days. Perioperative complication rate was 17.1%. Overall positive surgical margin rate was 24.19%, while biochemical recurrence was observed in 10.21% (19/186 patients). Modifications to the standard surgical technique were described in 13/18 studies. Modifications in port placement were described in 7/13 studies and performed in 19/88 (21.6%) patients. Surgical technique for the development of the Retzius space was reported in 13/18 studies. Data on lymphadenectomy were reported in 15/18 studies. Bilateral lymphadenectomy was described in 3/18 studies and performed in 4/89 (4.5%) patients; contralateral lymphadenectomy was reported in 7/18 studies and performed in 41/125 (32.8%) patients. RARP in RTRs can be considered relatively safe and feasible. Oncological results yielded significantly worse outcomes in terms of PSM and BCR rate compared to the data available in the published studies, with an overall complication rate highly variable among the studies included. On the other hand, low graft damage during the procedure was observed. Main criticisms came from different tumor screening protocols and scarce information about lymphadenectomy techniques and outcomes among the included studies.

Indexed as

kidney transplantationrecipientsrenal transplantrobot-assisted radical prostatectomy

Identifiers

PMID37959223
PMCPMC10649554
OpenAlexW4388197533

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.