ArticleInternational journal of molecular sciences2023
Effects of Factors Influencing Scar Formation on the Scar Microbiome in Patients with Burns.
Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07209007 (An Exploratory Study on the Dynamics of Microbiome Dysbiosis), which is not on this map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
An Exploratory Study on the Dynamics of Microbiome Dysbiosis (Microbial Imbalance) in the Skin and Gut Microbiome of Burn Patients
Who cites it
4 citing papers in PubMed.
- Misleading Presentation of Multilesional Benign Pathologies in the Breast: A Diagnostic Challenge.Cureus · 2026Article
- Factors Affecting Quality of Life in Post-Burn Patients: A Cross-Sectional Study in Indonesia.Annals of burns and fire disasters · 2025Article
- Causal relationships between skin microbiome and pathological scars: a bidirectional mendelian randomization study.Archives of dermatological research · 2024Article
- Multidisciplinary Management and Autologous Skin Grafting in a Patient with Severe Burns: A Case Study.Medicina (Kaunas, Lithuania) · 2024Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Skin microbiome dysbiosis has deleterious effects, and the factors influencing burn scar formation, which affects the scar microbiome composition, are unknown. Therefore, we investigated the effects of various factors influencing scar formation on the scar microbiome composition in patients with burns. We collected samples from the burn scar center and margin of 40 patients with burns, subgrouped by factors influencing scar formation. Scar microbiome composition-influencing factors were analyzed using univariate and multivariate analyses. Skin graft, hospitalization period, intensive care unit (ICU) admission, burn degree, sex, age, total body surface area burned (TBSA), time post-injury, transepidermal water loss, the erythrocyte sedimentation rate, and C-reactive protein levels were identified as factors influencing burn scar microbiome composition. Only TBSA and ICU admission were associated with significant differences in alpha diversity. Alpha diversity significantly decreased with an increase in TBSA and was significantly lower in patients admitted to the ICU than in those not admitted to the ICU. Furthermore, we identified microorganisms associated with various explanatory variables. Our cross-sectional systems biology study confirmed that various variables influence the scar microbiome composition in patients with burns, each of which is associated with various microorganisms. Therefore, these factors should be considered during the application of skin microbiota for burn scar management.
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Registered trials
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