Evidence map›Paper›PMID 37958972›Full record

ArticleInternational journal of molecular sciences2023

Mice Lacking PLAP-1/Asporin Show Alteration of Periodontal Ligament Structures and Acceleration of Bone Loss in Periodontitis.

Masaki Kinoshita, Satoru Yamada, Junichi Sasaki, Shigeki Suzuki, Tetsuhiro Kajikawa, Tomoaki Iwayama, Chiharu Fujihara, Satoshi Imazato, Shinya Murakami

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.6field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Masaki KinoshitaDepartment of Periodontology and Regenerative Dentistry, Osaka University Graduate School of Dentistry, Suita 565-0871, Osaka, Japan.
Satoru YamadaDepartment of Periodontology and Endodontolgy, Tohoku University Graduate School of Dentistry, Sendai 980-8575, Miyagi, Japan.
Junichi SasakiDepartment of Dental Biomaterials, Osaka University Graduate School of Dentistry, Suita 565-0871, Osaka, Japan.ORCID 0000-0002-0330-0397
Shigeki SuzukiDepartment of Periodontology and Endodontolgy, Tohoku University Graduate School of Dentistry, Sendai 980-8575, Miyagi, Japan.ORCID 0000-0003-0888-4050
Tetsuhiro KajikawaDepartment of Periodontology and Endodontolgy, Tohoku University Graduate School of Dentistry, Sendai 980-8575, Miyagi, Japan.
Tomoaki IwayamaDepartment of Periodontology and Regenerative Dentistry, Osaka University Graduate School of Dentistry, Suita 565-0871, Osaka, Japan.
Chiharu FujiharaDepartment of Periodontology and Regenerative Dentistry, Osaka University Graduate School of Dentistry, Suita 565-0871, Osaka, Japan.
Satoshi ImazatoDepartment of Dental Biomaterials, Osaka University Graduate School of Dentistry, Suita 565-0871, Osaka, Japan.
Shinya MurakamiDepartment of Periodontology and Regenerative Dentistry, Osaka University Graduate School of Dentistry, Suita 565-0871, Osaka, Japan.
The University of Osaka · JPTohoku University · JP

Funding

Japan Society for the Promotion of Science 17H04417, 20H03862 and 23H03077
6 · The paper itself

Abstract

Periodontal ligament-associated protein 1 (PLAP-1), also known as Asporin, is an extracellular matrix protein expressed in the periodontal ligament and plays a crucial role in periodontal tissue homeostasis. Our previous research demonstrated that PLAP-1 may inhibit TLR2/4-mediated inflammatory responses, thereby exerting a protective function against periodontitis. However, the precise roles of PLAP-1 in the periodontal ligament (PDL) and its relationship to periodontitis have not been fully explored. In this study, we employed

Indexed as

Alveolar Bone LossPeriodontitisAccelerationAnimalsCollagenExtracellular Matrix ProteinsMaleMiceMice, Inbred C57BLMice, KnockoutPeriodontal LigamentX-Ray MicrotomographyAspn protein, mouseCollagenExtracellular Matrix Proteinsextracellular matrixknockout animalsperiodontal ligamentperiodontitisPLAP-1/Asporinsmall leucine-rich repeat proteoglycan

Identifiers

PMID37958972
PMCPMC10649079
OpenAlexW4388380417

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.