Evidence map›Paper›PMID 37958923›Full record

ArticleInternational journal of molecular sciences2023

Lack of Evidence for the Role of the p.(Ser96Ala) Polymorphism in Histidine-Rich Calcium Binding Protein as a Secondary Hit in Cardiomyopathies.

Stephanie M van der Voorn, Esmée van Drie, Virginnio Proost, Kristina Dimitrova, Netherlands Acm/Pln Registry, Robert F Ernst, Cynthia A James, Crystal Tichnell, Brittney Murray, Hugh Calkins and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 3 countries.

Stephanie M van der VoornDepartment of Medical Physiology, Division Heart & Lungs, University Medical Center Utrecht, 3584 CM Utrecht, The Netherlands.ORCID 0000-0003-0934-3491
Esmée van DrieDepartment of Genetics, Division Heart & Lungs, University Medical Center Utrecht, 3584 CM Utrecht, The Netherlands.
Virginnio ProostDepartments of Clinical and Experimental Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centers Location Academic Medical Center, 1105 AZ Amsterdam, The Netherlands.
Kristina DimitrovaDepartment of Medical Physiology, Division Heart & Lungs, University Medical Center Utrecht, 3584 CM Utrecht, The Netherlands.
Netherlands Acm/Pln Registry
Robert F ErnstDepartment of Genetics, Division Heart & Lungs, University Medical Center Utrecht, 3584 CM Utrecht, The Netherlands.
Cynthia A JamesDepartment of Medicine, Division Cardiology, Johns Hopkins University, Baltimore, MD 21218, USA.ORCID 0000-0001-8040-4600
Crystal TichnellDepartment of Medicine, Division Cardiology, Johns Hopkins University, Baltimore, MD 21218, USA.
Brittney MurrayDepartment of Medicine, Division Cardiology, Johns Hopkins University, Baltimore, MD 21218, USA.
Hugh CalkinsDepartment of Medicine, Division Cardiology, Johns Hopkins University, Baltimore, MD 21218, USA.
Ardan M SagunerDepartment of Cardiology, University Heart Center Zurich, University Hospital Zurich, 8091 Zurich, Switzerland.ORCID 0000-0003-1896-0803
Firat DuruDepartment of Cardiology, University Heart Center Zurich, University Hospital Zurich, 8091 Zurich, Switzerland.ORCID 0000-0002-4748-0158
Patrick T EllinorCardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Connie R BezzinaDepartments of Clinical and Experimental Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centers Location Academic Medical Center, 1105 AZ Amsterdam, The Netherlands.
Sean J JurgensDepartments of Clinical and Experimental Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centers Location Academic Medical Center, 1105 AZ Amsterdam, The Netherlands.ORCID 0000-0002-1605-9782
J Peter van TintelenDepartment of Genetics, Division Heart & Lungs, University Medical Center Utrecht, 3584 CM Utrecht, The Netherlands.
Toon A B van VeenDepartment of Medical Physiology, Division Heart & Lungs, University Medical Center Utrecht, 3584 CM Utrecht, The Netherlands.
University Medical Center Utrecht · NLJohns Hopkins University · USBroad Institute · USAmsterdam UMC Location University of Amsterdam · NLUniversity of Zurich · CH

Funding

Swiss National Science Foundation 160327
6 · The paper itself

Abstract

Inherited forms of arrhythmogenic and dilated cardiomyopathy (ACM and DCM) are characterized by variable disease expression and age-related penetrance. Calcium (Ca

Indexed as

CardiomyopathiesCardiomyopathy, DilatedArrhythmias, CardiacCalciumCalcium-Binding ProteinsHistidineHumansPolymorphism, GeneticCalciumCalcium-Binding ProteinsHistidineHRC protein, humanarrhythmiacardiomyopathiesgenetic modifiergeneticsheart failure

Identifiers

PMID37958923
PMCPMC10648441
OpenAlexW4388289094

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.